200004-40-6

Usage

Uses

Used in Pharmaceutical Synthesis:
(1S)-3-chloro-1-(4-fluorophenyl)propan-1-ol is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare.
Used in Agrochemical Development:
In the agrochemical industry, (1S)-3-chloro-1-(4-fluorophenyl)propan-1-ol serves as an intermediate in the creation of pesticides and other agricultural chemicals. Its role in these products is crucial for enhancing crop protection and ensuring food security.
Used in Medicinal Chemistry Research:
(1S)-3-chloro-1-(4-fluorophenyl)propan-1-ol is utilized in the field of medicinal chemistry for research and development purposes. Its potential biological activity and unique stereochemistry make it an important compound for studying molecular interactions and identifying new drug targets.
Used in Drug Development:
Owing to its potential biological activity, (1S)-3-chloro-1-(4-fluorophenyl)propan-1-ol is used in the development of new drugs. Its unique chemical structure and stereochemistry play a significant role in understanding its mechanism of action and its interaction with biological targets, which is essential for the creation of effective treatments.

InChI:InChI=1/C9H10ClFO/c10-6-5-9(12)7-1-3-8(11)4-2-7/h1-4,9,12H,5-6H2/t9-/m0/s1

Upstream product

• 347-93-3 3-chloro-4'-fluoropropiophenone 
• 123-20-6 vinyl n-butyrate 
• 31736-75-1 3-chloro-1-(4-fluorophenyl)propan-1-ol 

Downstream Products

• 1238698-08-2 C₁₆H₁₆ClFO 
• 923570-24-5 4S-(4-benzyloxy-phenyl)-3S-(4-fluoro-phenyl)-1-[3-(4-fluoro-phenyl)-3S-hydroxy-propyl]-azetidin-2-one 
• 923570-22-3 4R-(4-benzyloxy-phenyl)-3R-(4-fluoro-phenyl)-1-[3-(4-fluoro-phenyl)-3S-hydroxy-propyl]-azetidin-2-one 
• 926657-23-0 (S)-1-(4-Fluoro-phenyl)-3-iodo-propan-1-ol 

Relevant academic research and scientific papers

A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

A convenient, versatile, and green CBS-asymmetric reduction of aryl and heteroaryl ketones has been developed by using the microreactor technology. The study demonstrates that it is possible to handle borane solution safely within microreactors and that the reaction performs well using 2-MeTHF as a greener solvent.

Lipase-catalyzed synthesis of both enantiomers of 3-chloro-1-arylpropan-1- ols

The lipase-catalyzed synthesis of both enantiomers of 3-chloro-1-(4- fluorophenyl)propan-1-ol, 3-chloro-1-(4-iodophenyl)propan-1-ol, and 3-chloro-1-phenylpropan-1-ol is described. The procedure is based on the enantiomer-selective acylation of the racemic alcohols in presence of lipase from Pseudomonas fluorescens (LAK) followed by the lipase from Candida rugosa (CRL) mediated hydrolysis of previously obtained enantiomerically enriched 1-aryl-3-chloropropyl esters. For the production of enantiopure (S)-1-aryl-3-chloropropan-1-ols (99% ee, 34-42% yield) the reactions were stopped at higher conversions than the theoretical optimum of 50%, while for enantiopure (R)-1-aryl-3-chloropropyl acetates (99% ee) the reactions were stopped at lower conversions. The latter compounds were enzymatically hydrolyzed into the corresponding (R)-1-aryl-3-chloropropan-1-ols (97-99% ee, 18-24% yield). The absolute configuration of the resolution products was determined by VCD measurements combined with quantum chemical calculations. Georg Thieme Verlag Stuttgart - New York.

PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE

Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically enriched piperidine compounds to treat gastrointestinal diseases, and a method of treating gastro

Ezetimibe analogs with a reorganized azetidinone ring: Design, synthesis, and evaluation of cholesterol absorption inhibitions

The underlying principle of drug design in this paper is that the maximum retention of the functional groups that exist in the marketed drug would provide a higher probability for comparable safety while the conformational changes in the newly created ana

BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS

The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula (I). Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.

Asymmetric Synthesis of 2-Aryl Substituted Oxetanes by Enantioselective Reduction of β-Halogenoketones using Lithium Borohydride modified with N,N'-Dibenzoylcystine

Optically active 2-aryl substituted oxetanes are synthesised in high enantiomeric excesses (up to 89percent e.e.) via enantioselective reduction of β-halogenoketones with lithium borohydride using (R,R')-N,N'-dibenzoylcystine and t-butyl alcohols as ligands.