(3-Methoxy-2-nitro-phenyl)-methyl-amine

Base Information

• Chemical Name: (3-Methoxy-2-nitro-phenyl)-methyl-amine
• CAS No.: 1143575-95-4
• Molecular Formula: C8H10N2O3
• Molecular Weight: 182.179
• Mol file: 1143575-95-4.mol

Synonyms:(3-Methoxy-2-nitro-phenyl)-methyl-amine;3-Methoxy-N-methyl-2-nitroaniline

Chemical Property of (3-Methoxy-2-nitro-phenyl)-methyl-amine

Chemical Property:

• PSA: 67.08000
• LogP: 2.24130

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-N-methyl-2-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-Methoxy-2-nitro-phenyl)-methyl-amine

There total 4 articles about (3-Methoxy-2-nitro-phenyl)-methyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3-methoxy-2-nitrophenyl)-(methyl)carbamate (1143575-94-3) → (3-methoxy-2-nitrophenyl)-(methyl)amine (1143575-95-4)

Guidance literature:

tert-butyl (3-methoxy-2-nitrophenyl)-(methyl)carbamate; With hydrogenchloride; In water; ethyl acetate; at 60 ℃; for 5h;

With sodium hydrogencarbonate;

Reference yield:

1-fluoro-3-methoxy-2-nitrobenzene (641-49-6) + methylamine (74-89-5) → (3-methoxy-2-nitrophenyl)-(methyl)amine (1143575-95-4)

Guidance literature:

In methanol; for 10h; Reflux;

Reference yield:

3-methoxy-2-nitrobenzoic acid (4920-80-3) → (3-methoxy-2-nitrophenyl)-(methyl)amine (1143575-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / 6 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 20 °C

3.1: hydrogenchloride / water; ethyl acetate / 5 h / 60 °C

With hydrogenchloride; diphenyl phosphoryl azide; sodium hydride; triethylamine; In water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

1-fluoro-3-methoxy-2-nitrobenzene

methylamine

tert-butyl (3-methoxy-2-nitrophenyl)-(methyl)carbamate

3-methoxy-2-nitrobenzoic acid

Downstream raw materials:

3-methoxy-N₁-methylbenzene-1,2-diamine

2-chloro-4-methoxy-1-methyl-1H-benzimidazole

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