10-(3-(Diethylamino)propyl)phenothiazine

Base Information

• Chemical Name: 10-(3-(Diethylamino)propyl)phenothiazine
• CAS No.: 47205-14-1
• Molecular Formula: C19H24N2S
• Molecular Weight: 312.479
• European Community (EC) Number: 622-221-7
• DSSTox Substance ID: DTXSID30357514
• Wikidata: Q82137458
• Mol file: 47205-14-1.mol

Synonyms:10-(3-(DIETHYLAMINO)PROPYL)PHENOTHIAZINE;47205-14-1;N,N-diethyl-3-phenothiazin-10-ylpropan-1-amine;Oprea1_805307;SCHEMBL4247663;DTXSID30357514;AKOS024338464;AB00109510-01;US9504692, 3939;N,N-diethyl-3-(10H-phenothiazin-10-yl)-1-propanamine

Chemical Property of 10-(3-(Diethylamino)propyl)phenothiazine

Chemical Property:

• Boiling Point: 213-215 °C(Press: 1.5 Torr)
• PSA: 31.78000
• Density: 1.100±0.06 g/cm3(Predicted)
• LogP: 5.08620
• XLogP3: 5.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 312.16601995
• Heavy Atom Count: 22
• Complexity: 309

Purity/Quality:

10-(3-(DIETHYLAMINO)PROPYL)PHENOTHIAZINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCCN1C2=CC=CC=C2SC3=CC=CC=C31

Technology Process of 10-(3-(Diethylamino)propyl)phenothiazine

There total 9 articles about 10-(3-(Diethylamino)propyl)phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(N,N-diethylamino)propyl phenothiazine carbamate (72331-97-6) → 10H-phenothiazine (92-84-2) + chlorproethazine (47205-14-1)

Guidance literature:

at 190 - 200 ℃; for 0.5h; Yield given. Yields of byproduct given;

DOI:10.1021/jo01292a048

Reference yield:

10H-phenothiazine (92-84-2) → chlorproethazine (47205-14-1)

Guidance literature:

Multi-step reaction with 2 steps

2: copper

With copper;

DOI:10.1021/ja01234a013

Reference yield:

10-(3-chloropropyl)-10H-phenothiazine (5909-59-1) + diethylamine (109-89-7) → chlorproethazine (47205-14-1)

Guidance literature:

With copper;

DOI:10.1021/ja01234a013

upstream raw materials:

10H-phenothiazine

3-diethylaminopropyl chloride

10-(3-chloropropyl)-10H-phenothiazine

diethylamine

Downstream raw materials:

diethyl-[3-(5-oxo-5λ⁴-phenothiazin-10-yl)-propyl]-amine oxide