Technology Process of N-(5-Fluoro-3-formylpyridin-2-yl)pivalamide
There total 5 articles about N-(5-Fluoro-3-formylpyridin-2-yl)pivalamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(5-fluoropyridin-2-yl)-2,2-dimethylpropanamide;
With
tert.-butyl lithium;
In
hexanes; diethyl ether;
at -78 ℃;
Inert atmosphere;
N,N-dimethyl-formamide;
In
hexanes; diethyl ether;
at -78 - 20 ℃;
With
hydrogenchloride; water;
In
hexanes; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere
2.1: tert.-butyl lithium / diethyl ether / 1 h / -78 °C / Inert atmosphere
2.2: 2 h / -60 °C / Inert atmosphere
With
tert.-butyl lithium; triethylamine;
In
diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; palladium diacetate / 1,4-dioxane / 50 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 20 °C
3.1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere
4.1: tert.-butyl lithium / diethyl ether / 1 h / -78 °C / Inert atmosphere
4.2: 2 h / -60 °C / Inert atmosphere
With
tert.-butyl lithium; palladium diacetate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid;
In
1,4-dioxane; diethyl ether; dichloromethane;
