2-Amino-5-fluoro-pyridine-3-carbaldehyde

Base Information

• Chemical Name: 2-Amino-5-fluoro-pyridine-3-carbaldehyde
• CAS No.: 1188433-88-6
• Molecular Formula: C6H5FN2O
• Molecular Weight: 140.117
• Mol file: 1188433-88-6.mol

Synonyms:2-Amino-5-fluoro-pyridine-3-carbaldehyde

Chemical Property of 2-Amino-5-fluoro-pyridine-3-carbaldehyde

Chemical Property:

• PSA: 55.98000
• LogP: 1.19660

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-fluoro-pyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of 2-Amino-5-fluoro-pyridine-3-carbaldehyde

There total 5 articles about 2-Amino-5-fluoro-pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5-fluoro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide (1188433-81-9) → 2-amino-5-fluoropyridine-3-carbaldehyde (1188433-88-6)

Guidance literature:

N-(5-fluoro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide; With hydrogenchloride; water; at 100 ℃; for 0.75h;

With sodium hydrogencarbonate; In water; at 20 ℃; pH=5;

Reference yield:

2-amino-5-fluoropyridine (21717-96-4) → 2-amino-5-fluoropyridine-3-carbaldehyde (1188433-88-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / diethyl ether / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -60 °C / Inert atmosphere

3.1: hydrogenchloride / water / 2 h / 100 °C

With hydrogenchloride; tert.-butyl lithium; triethylamine; In diethyl ether; dichloromethane; water;

Reference yield:

N-(5-fluoropyridin-2-yl)-2,2-dimethylpropanamide (784155-54-0) → 2-amino-5-fluoropyridine-3-carbaldehyde (1188433-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether / 1 h / -78 °C / Inert atmosphere

1.2: 2 h / -60 °C / Inert atmosphere

2.1: hydrogenchloride / water / 2 h / 100 °C

With hydrogenchloride; tert.-butyl lithium; In diethyl ether; water;

upstream raw materials:

N-(5-fluoro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide

2-chloro-5-fluoropyridine

2-amino-5-fluoropyridine

N-(5-fluoropyridin-2-yl)-2,2-dimethylpropanamide

Downstream raw materials:

2-(6-fluoro-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)cyclohexane-1,3-dione

5-fluoro-2-(2-trifluoromethyl-phenylamino)-pyridine-3-carboxyaldehyde

Refernces

• 1、 -. "HERBICIDAL COMPOUNDS". Page/Page column 35. . Retrieved 2010/11/03.