4-Bromo-1-tosylpyrrolidin-3-one

Base Information

Chemical Name:4-Bromo-1-tosylpyrrolidin-3-one
CAS No.:170456-82-3
Molecular Formula:C11H12BrNO3S
Molecular Weight:318.191
Hs Code.:2933990090
DSSTox Substance ID:DTXSID80570312
Mol file:170456-82-3.mol

Synonyms:4-Bromo-1-tosylpyrrolidin-3-one;170456-82-3;4-BROMO-1-(TOLUENE-4-SULFONYL)-PYRROLIDIN-3-ONE;4-bromo-1-(4-methylphenyl)sulfonylpyrrolidin-3-one;4-bromo-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-one;SCHEMBL3621840;DTXSID80570312;GZHSUXXRBWNDMF-UHFFFAOYSA-N;VGA45682;MFCD18914395;AKOS024262107;SB34203;BS-15633;CS-0341247;D82872;4-bromo-1-(4-methylbenzenesulfonyl)pyrrolidin-3-one;4-Bromo-1-(4-methylbenzene-1-sulfonyl)pyrrolidin-3-one

Suppliers and Price of 4-Bromo-1-tosylpyrrolidin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 97%
500mg
$ 399.00

J&W Pharmlab
4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 97%
250mg
$ 249.00

J&W Pharmlab
4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 97%
100mg
$ 175.00

J&W Pharmlab
4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 97%
50mg
$ 137.00

J&W Pharmlab
4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 97%
5g
$ 2445.00

J&W Pharmlab
4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 97%
1g
$ 698.00

Crysdot
4-Bromo-1-tosylpyrrolidin-3-one 95+%
1g
$ 608.00

Chemenu
4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 95%
1g
$ 574.00

Total 8 raw suppliers

Chemical Property of 4-Bromo-1-tosylpyrrolidin-3-one

Chemical Property:

Boiling Point:446.1±55.0 °C(Predicted)
PKA:-10?+-.0.40(Predicted)
PSA：62.83000
Density:1.638±0.06 g/cm3(Predicted)
LogP:2.35060
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:316.97213
Heavy Atom Count:17
Complexity:395

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)N2CC(C(=O)C2)Br

Technology Process of 4-Bromo-1-tosylpyrrolidin-3-one

There total 5 articles about 4-Bromo-1-tosylpyrrolidin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-bromo-1-(toluene-4-sulfonyl)pyrrolidin-3-ol: 170456-84-5
4-bromo-1-(toluene-4-sulfonyl)pyrrolidin-3-ol

4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one: 170456-82-3
4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

: 73696-28-3
1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-one

4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one: 170456-82-3
4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one

Guidance literature:: With bromine; acetic acid; at 46 - 50 ℃; for 0.0833333h;
DOI:10.3987/COM-94-6916

Reference yield:

: 16851-72-2
1-[(4-methylphenyl)sulfonyl]-2,5-dihydro-1H-pyrrole

4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one: 170456-82-3
4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NBS, H₂O / dimethylsulfoxide

2: 81 percent / (n-Bu)3SnH / tetrahydrofuran / 5 h / Heating

3: 77 percent / PCC / CH₂Cl₂ / Ambient temperature

4: Br₂, AcOH / 0.08 h / 46 - 50 °C

With N-Bromosuccinimide; water; bromine; tri-n-butyl-tin hydride; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.3987/COM-94-6916