2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol

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Chemical Name:2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol
CAS No.:1004764-08-2
Molecular Formula:C₂₁H₂₃ClN₂O₄S₂
Molecular Weight:467.01
Hs Code.:

Synonyms:2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol

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Chemical Property of 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol

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Technology Process of 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol

There total 5 articles about 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 911134-67-3
4-(3-chloropropoxy)benzenecarbothioamide

4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one: 170456-82-3
4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one

: 1004764-08-2
2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

: 619-57-8
p-hydroxybenzamide

: 1004764-08-2
2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / ethyl acetate / 24 h / Reflux

2: Lawessons reagent / chloroform / 12 h / 22 °C

3: N,N-dimethyl-formamide / 2 h / 60 °C

With Lawessons reagent; potassium carbonate; In chloroform; ethyl acetate; N,N-dimethyl-formamide; 3: Hantzsch condensation;
DOI:10.1002/cmdc.201100248

Reference yield:

: 16851-72-2
1-[(4-methylphenyl)sulfonyl]-2,5-dihydro-1H-pyrrole

: 1004764-08-2
2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; water / dimethyl sulfoxide; acetonitrile / 2 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: N,N-dimethyl-formamide / 2 h / 60 °C

With N-Bromosuccinimide; water; Dess-Martin periodane; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 3: Hantzsch condensation;
DOI:10.1002/cmdc.201100248