2-Benzhydryl-2-azaspiro[3.3]heptan-5-ol

Base Information

• Chemical Name: 2-Benzhydryl-2-azaspiro[3.3]heptan-5-ol
• CAS No.: 1263296-81-6
• Molecular Formula: C19H21NO
• Molecular Weight: 279.382
• Hs Code.: 2933990090
• Mol file: 1263296-81-6.mol

Synonyms:2-Benzhydryl-2-azaspiro[3.3]heptan-5-ol;2-(diphenylmethyl)-2-azaspiro[3.3]heptan-5-ol

Chemical Property of 2-Benzhydryl-2-azaspiro[3.3]heptan-5-ol

Chemical Property:

• PSA: 23.47000
• LogP: 3.17060

Purity/Quality:

99%, ^*data from raw suppliers

2-Benzhydryl-2-azaspiro[3.3]heptan-5-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzhydryl-2-azaspiro[3.3]heptan-5-ol

There total 3 articles about 2-Benzhydryl-2-azaspiro[3.3]heptan-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-(diphenylmethyl)-6-azaspiro[3.3]heptan-1-one (1263296-80-5) → 2-benzhydryl-2-azaspiro[3.3]heptan-5-ol (1263296-81-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol103050c

Reference yield:

6-benzhydryl-6-aza-8-oxa-dispiro[2.0.3.1]octane (1263296-79-2) → 2-benzhydryl-2-azaspiro[3.3]heptan-5-ol (1263296-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium iodide / tetrahydrofuran; toluene / 15 h / 20 - 50 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; lithium iodide; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/ol103050c

Reference yield:

N-benzhydryl 3-azetidinone (40320-60-3) → 2-benzhydryl-2-azaspiro[3.3]heptan-5-ol (1263296-81-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.08 h / -40 °C / Inert atmosphere

1.2: 4 h / -40 °C / Inert atmosphere

2.1: lithium iodide / tetrahydrofuran; toluene / 15 h / 20 - 50 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; potassium hexamethylsilazane; lithium iodide; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/ol103050c

upstream raw materials:

6-benzhydryl-6-aza-8-oxa-dispiro[2.0.3.1]octane

6-(diphenylmethyl)-6-azaspiro[3.3]heptan-1-one

N-benzhydryl 3-azetidinone

Downstream raw materials:

(R,S)-2-benzhydryl-2-azaspiro[3.3]heptan-5-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1263296-81-6 2-Benzhydryl-2-azaspiro[3.3]heptan-5-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send