2-benzhydryl-2-azaspiro[3.3]heptan-5-aMine

Base Information

• Chemical Name: 2-benzhydryl-2-azaspiro[3.3]heptan-5-aMine
• CAS No.: 1263296-82-7
• Molecular Formula: C19H22N2
• Molecular Weight: 278.397
• Hs Code.: 2933990090
• Mol file: 1263296-82-7.mol

Synonyms:2-benzhydryl-2-azaspiro[3.3]heptan-5-aMine;2-(diphenylmethyl)-2-azaspiro[3.3]heptan-5-amine

Chemical Property of 2-benzhydryl-2-azaspiro[3.3]heptan-5-aMine

Chemical Property:

• Boiling Point: 393.0±42.0 °C(Predicted)
• PKA: 10.06±0.20(Predicted)
• PSA: 29.26000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 3.83730

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Amino-2-diphenylmethyl-2-azaspiro[3.3]heptane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzhydryl-2-azaspiro[3.3]heptan-5-aMine

There total 4 articles about 2-benzhydryl-2-azaspiro[3.3]heptan-5-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-benzhydryl-2-azaspiro[3.3]heptan-5-ol (1263296-81-6) → (R,S)-2-benzhydryl-2-azaspiro[3.3]heptan-5-amine (1263296-82-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol103050c

Reference yield:

6-benzhydryl-6-aza-8-oxa-dispiro[2.0.3.1]octane (1263296-79-2) → (R,S)-2-benzhydryl-2-azaspiro[3.3]heptan-5-amine (1263296-82-7)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium iodide / tetrahydrofuran; toluene / 15 h / 20 - 50 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; lithium aluminium tetrahydride; lithium iodide; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/ol103050c

Reference yield:

6-(diphenylmethyl)-6-azaspiro[3.3]heptan-1-one (1263296-80-5) → (R,S)-2-benzhydryl-2-azaspiro[3.3]heptan-5-amine (1263296-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 16 h / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; lithium aluminium tetrahydride; In tetrahydrofuran; methanol;

DOI:10.1021/ol103050c

upstream raw materials:

6-benzhydryl-6-aza-8-oxa-dispiro[2.0.3.1]octane

6-(diphenylmethyl)-6-azaspiro[3.3]heptan-1-one

2-benzhydryl-2-azaspiro[3.3]heptan-5-ol

N-benzhydryl 3-azetidinone

Downstream raw materials:

(RS)-tert-butyl 2-(4-chlorophenylsulfonyl)-2-azaspiro[3.3]heptan-5-ylcarbamate

(RS)-tert-butyl 2-benzhydryl-2-azaspiro[3.3]heptan-5-ylcarbamate

Refernces