2-broMo-5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazole

Base Information

Chemical Name:2-broMo-5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazole
CAS No.:1258440-64-0
Molecular Formula:C11H10BrClN2OS
Molecular Weight:333.636
Hs Code.:
Mol file:1258440-64-0.mol

Synonyms:2-broMo-5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazole

Suppliers and Price of 2-broMo-5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 2-broMo-5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazole

Chemical Property:

PSA：63.25000
LogP:4.40820

Purity/Quality:: >97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-broMo-5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazole

There total 3 articles about 2-broMo-5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1258440-61-7
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-amine

: 1258440-64-0
2-bromo-5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazole

Guidance literature:: With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield: 31.2%

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 79-19-6
thiosemicarbazide

: 1258440-64-0
2-bromo-5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazole

Guidance literature:: 3-chloro-4-isopropoxy-benzoic acid; thiosemicarbazide; With trichlorophosphate; In acetonitrile; at 20 - 90 ℃; for 18.3333h;

With sodium hydroxide; In water; for 0.5h; pH=12; Cooling with ice;

Reference yield:

: 213767-19-2
3-chloro-4-[(1-methylethyl)oxy]benzoyl chloride

: 1258440-64-0
2-bromo-5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 19 h / 20 - 90 °C

2: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 20 °C

With tert.-butylnitrite; copper(ll) bromide; trichlorophosphate; In acetonitrile;
DOI:10.1021/acs.jmedchem.5b01512