5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-aMine

Base Information

Chemical Name:5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-aMine
CAS No.:1258440-61-7
Molecular Formula:C11H12ClN3OS
Molecular Weight:269.755
Hs Code.:
Mol file:1258440-61-7.mol

Synonyms:5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-aMine

Suppliers and Price of 5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-aMine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-aMine

Chemical Property:

Boiling Point:434.3±55.0 °C(Predicted)
PKA:2.74±0.10(Predicted)
PSA：89.27000
Density:1.333±0.06 g/cm3(Predicted)
LogP:3.80910

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-aMine

There total 3 articles about 5-{3-chloro-4-[(1-Methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.6%

: 79-19-6
thiosemicarbazide

: 213767-19-2
3-chloro-4-[(1-methylethyl)oxy]benzoyl chloride

: 1258440-61-7
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-amine

Guidance literature:: thiosemicarbazide; 3-chloro-4-[(1-methylethyl)oxy]benzoyl chloride; With trichlorophosphate; at 90 ℃; for 3h;

With sodium hydroxide; at 20 ℃; Cooling with ice;

Reference yield: 31.2%

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 79-19-6
thiosemicarbazide

: 1258440-61-7
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-amine

Guidance literature:: With trichlorophosphate; at 20 - 90 ℃; for 18.3333h; Product distribution / selectivity;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1258440-61-7
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16.5 h / 20 °C

2: trichlorophosphate / 19 h / 20 - 90 °C

With oxalyl dichloride; N,N-dimethyl-formamide; trichlorophosphate; In dichloromethane;
DOI:10.1021/acs.jmedchem.5b01512