GSK-3beta Inhibitor XXVI(GSK-3b)

Base Information

Chemical Name:GSK-3beta Inhibitor XXVI(GSK-3b)
CAS No.:871843-09-3
Molecular Formula:C₂₁H₁₈N₄O
Molecular Weight:342.4
Hs Code.:

Synonyms:GSK-3beta Inhibitor XXVI(GSK-3b);4,5-bis(1-Methyl-1H-indol-3-yl)-1,2-dihydropyrazol-3-one;GSK-3b

Suppliers and Price of GSK-3beta Inhibitor XXVI(GSK-3b)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
GSK3B
96Tests
$ 729.00

Biorbyt Ltd
GSK3B
10 μg
$ 712.30

Total 3 raw suppliers

Chemical Property of GSK-3beta Inhibitor XXVI(GSK-3b)

Chemical Property:

PSA：58.51000
LogP:4.02040

Purity/Quality:

99%, ^*data from raw suppliers

GSK3B ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of GSK-3beta Inhibitor XXVI(GSK-3b)

There total 3 articles about GSK-3beta Inhibitor XXVI(GSK-3b) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 871843-19-5
ethyl 2,3-bis(1-methyl-1H-indol-3-yl)-3-oxopropanoate

: 871843-09-3
4,5-bis(1-Methyl-1H-indol-3-yl)-1,2-dihydropyrazol-3-one

Guidance literature:: With camphoric acid; hydrazine hydrate; In ethanol; for 26h; Heating;
DOI:10.1016/j.bmc.2005.09.059

Reference yield:

: 32387-21-6
1-methyl-3-indolecarboxylic acid

: 871843-09-3
4,5-bis(1-Methyl-1H-indol-3-yl)-1,2-dihydropyrazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: SOCl₂; DMF / 20 h / 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C

2.2: 52 percent / tetrahydrofuran / -78 - 20 °C

3.1: 80 percent / hydrazine monohydrate; camphoric acid / ethanol / 26 h / Heating

With thionyl chloride; camphoric acid; hydrazine hydrate; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2005.09.059

Reference yield:

: 126921-19-5
3-chlorocarbonyl-1-methylindole

: 871843-09-3
4,5-bis(1-Methyl-1H-indol-3-yl)-1,2-dihydropyrazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C

1.2: 52 percent / tetrahydrofuran / -78 - 20 °C

2.1: 80 percent / hydrazine monohydrate; camphoric acid / ethanol / 26 h / Heating

With camphoric acid; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2005.09.059