GSK-3beta Inhibitor XXVI(GSK-3b)

Base Information

• Chemical Name: GSK-3beta Inhibitor XXVI(GSK-3b)
• CAS No.: 871843-09-3
• Molecular Formula: C₂₁H₁₈N₄O
• Molecular Weight: 342.4
• Mol file: 871843-09-3.mol

Synonyms:GSK-3beta Inhibitor XXVI(GSK-3b);4,5-bis(1-Methyl-1H-indol-3-yl)-1,2-dihydropyrazol-3-one;GSK-3b

Chemical Property of GSK-3beta Inhibitor XXVI(GSK-3b)

Chemical Property:

• PSA: 58.51000
• LogP: 4.02040

Purity/Quality:

99%min. ^*data from raw suppliers

GSK3B ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GSK-3beta Inhibitor XXVI(GSK-3b)

There total 3 articles about GSK-3beta Inhibitor XXVI(GSK-3b) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 2,3-bis(1-methyl-1H-indol-3-yl)-3-oxopropanoate (871843-19-5) → 4,5-bis(1-Methyl-1H-indol-3-yl)-1,2-dihydropyrazol-3-one (871843-09-3)

Guidance literature:

With camphoric acid; hydrazine hydrate; In ethanol; for 26h; Heating;

DOI:10.1016/j.bmc.2005.09.059

Reference yield:

1-methyl-3-indolecarboxylic acid (32387-21-6) → 4,5-bis(1-Methyl-1H-indol-3-yl)-1,2-dihydropyrazol-3-one (871843-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: SOCl₂; DMF / 20 h / 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C

2.2: 52 percent / tetrahydrofuran / -78 - 20 °C

3.1: 80 percent / hydrazine monohydrate; camphoric acid / ethanol / 26 h / Heating

With thionyl chloride; camphoric acid; hydrazine hydrate; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2005.09.059

Reference yield:

3-chlorocarbonyl-1-methylindole (126921-19-5) → 4,5-bis(1-Methyl-1H-indol-3-yl)-1,2-dihydropyrazol-3-one (871843-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C

1.2: 52 percent / tetrahydrofuran / -78 - 20 °C

2.1: 80 percent / hydrazine monohydrate; camphoric acid / ethanol / 26 h / Heating

With camphoric acid; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2005.09.059

upstream raw materials:

ethyl 2,3-bis(1-methyl-1H-indol-3-yl)-3-oxopropanoate

1-methyl-3-indolecarboxylic acid

3-chlorocarbonyl-1-methylindole

Refernces