trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester

Base Information

• Chemical Name: trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester
• CAS No.: 1227068-83-8
• Molecular Formula: C₇H₇F₅O₃S
• Molecular Weight: 266.189
• Mol file: 1227068-83-8.mol

Synonyms:trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester

Chemical Property of trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester

There total 3 articles about trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + 4,4-difluorocyclohexanone (22515-18-0) → trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester (1227068-83-8)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201910871

Reference yield: 66.0%

trifluoromethylsulfonic anhydride (358-23-6) + 4,4-difluorocyclohexanone (22515-18-0) → trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester (1227068-83-8)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02601

Reference yield:

4,4-difluorocyclohexanone (22515-18-0) + phenyl trifluoromethylsulfide (456-56-4) → trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester (1227068-83-8)

Guidance literature:

4,4-difluorocyclohexanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

phenyl trifluoromethylsulfide; In tetrahydrofuran; at -78 - 20 ℃; for 16h;

upstream raw materials:

trifluoromethylsulfonic anhydride

4,4-difluorocyclohexanone

N,N-phenylbistrifluoromethane-sulfonimide

phenyl trifluoromethylsulfide

Downstream raw materials:

2-(4,4-difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol

AD-033-2