2-Chloro-6-(hydroxymethyl)-4-[2-(trimethylsilyl)ethynyl]pyridin-3-ol

Base Information

Chemical Name:2-Chloro-6-(hydroxymethyl)-4-[2-(trimethylsilyl)ethynyl]pyridin-3-ol
CAS No.:208519-38-4
Molecular Formula:C11H14ClNO2Si
Molecular Weight:255.776
Hs Code.:2933399090
DSSTox Substance ID:DTXSID90441145
Wikidata:Q82257768
Mol file:208519-38-4.mol

Synonyms:208519-38-4;2-chloro-6-(hydroxymethyl)-4-[2-(trimethylsilyl)ethynyl]pyridin-3-ol;2-chloro-6-(hydroxymethyl)-4-(2-trimethylsilylethynyl)pyridin-3-ol;SCHEMBL842579;DTXSID90441145;UPUKXPTXCGNQJR-UHFFFAOYSA-N;MFCD12827784;AKOS005072931;GD-0009;2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol

Suppliers and Price of 2-Chloro-6-(hydroxymethyl)-4-[2-(trimethylsilyl)ethynyl]pyridin-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-Chloro-3-hydroxy-6-methoxy-4-[2-(trimethylsilyl)ethynyl]pyridine
500 mg
$ 352.00

SynQuest Laboratories
2-Chloro-3-hydroxy-6-methoxy-4-[2-(trimethylsilyl)ethynyl]pyridine
1 g
$ 464.00

Matrix Scientific
2-Chloro-6-methoxy-4-[2-(trimethylsilyl)ethynyl]-3-pyridinol >95%
1g
$ 603.00

Apolloscientific
2-Chloro-3-hydroxy-6-methoxy-4-[2-(trimethylsilyl)ethynyl]pyridine
1g
$ 421.00

Apolloscientific
2-Chloro-3-hydroxy-6-methoxy-4-[2-(trimethylsilyl)ethynyl]pyridine
500mg
$ 319.00

American Custom Chemicals Corporation
2-CHLORO-6-METHOXY-4-[2-(TRIMETHYLSILYL)ETHYNYL]-3-PYRIDINOL 95.00%
500MG
$ 466.20

American Custom Chemicals Corporation
2-CHLORO-6-METHOXY-4-[2-(TRIMETHYLSILYL)ETHYNYL]-3-PYRIDINOL 95.00%
1G
$ 962.35

AK Scientific
2-Chloro-6-methoxy-4-[2-(trimethylsilyl)ethynyl]-3-pyridinol
1g
$ 864.00

Total 2 raw suppliers

Chemical Property of 2-Chloro-6-(hydroxymethyl)-4-[2-(trimethylsilyl)ethynyl]pyridin-3-ol

Chemical Property:

Melting Point:96-98°
PSA：53.35000
LogP:2.16180
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:255.0482329
Heavy Atom Count:16
Complexity:304

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3-hydroxy-6-methoxy-4-[2-(trimethylsilyl)ethynyl]pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[Si](C)(C)C#CC1=C(C(=NC(=C1)CO)Cl)O

Technology Process of 2-Chloro-6-(hydroxymethyl)-4-[2-(trimethylsilyl)ethynyl]pyridin-3-ol

There total 4 articles about 2-Chloro-6-(hydroxymethyl)-4-[2-(trimethylsilyl)ethynyl]pyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 208519-37-3
2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine

: 1066-54-2
trimethylsilylacetylene

: 208519-38-4
2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; chloroform;
DOI:10.1021/jm9801049

Reference yield: 92.0%

: bis(triphenylphosphine)palladium(II) dichloride

: 208519-37-3
2-chloro-3-hydroxy-6-(hydroxymethyl)-4-iodopyridine

: 1066-54-2
trimethylsilylacetylene

: 208519-38-4
2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol

Guidance literature:: With triethanolamine; copper(I) iodide; In tetrahydrofuran; chloroform;

Reference yield:

: 6636-78-8
2-chloro-3-hydroxypyridine

: 208519-38-4
2-chloro-6-(hydroxymethyl)-4-[(trimethylsilyl)ethynyl]-3-pyridinol

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaHCO₃ / 15 h / 90 °C

2: aq. NaHCO₃; I₂ / 48 h / 20 °C

3: 11.4 g / Pd(PPh₃)2Cl₂; CuI; Et₃N / tetrahydrofuran; CHCl₃ / 3 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; chloroform; 3: Sonogashira coupling;
DOI:10.1021/jm0602413