3-(aminomethyl)-5-bromobenzonitrile

Base Information

• Chemical Name: 3-(aminomethyl)-5-bromobenzonitrile
• CAS No.: 1177558-50-7
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.061
• Mol file: 1177558-50-7.mol

Synonyms:3-(aminomethyl)-5-bromobenzonitrile

Chemical Property of 3-(aminomethyl)-5-bromobenzonitrile

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(aminomethyl)-5-bromobenzonitrile

There total 8 articles about 3-(aminomethyl)-5-bromobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-bromo-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzonitrile (1177558-49-4) → 3-(aminomethyl)-5-bromobenzonitrile (1177558-50-7)

Guidance literature:

With hydrazine hydrate; In ethanol; water; for 3h; Reflux;

Reference yield:

5-bromo-1,3-xylene (556-96-7) → 3-(aminomethyl)-5-bromobenzonitrile (1177558-50-7)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 7 h / Reflux

2.1: calcium carbonate / 1,4-dioxane; water / 16 h / Reflux

3.1: potassium permanganate / water; acetone / 1 h / Reflux

4.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / Reflux

4.2: 1 h / 20 °C

5.1: phosphorus pentoxide / chloroform / 48 h / Reflux

6.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 10 h / Reflux

7.1: N,N-dimethyl-formamide / 4 h / Reflux

8.1: hydrazine hydrate / ethanol / 3 h / Reflux

With potassium permanganate; N-Bromosuccinimide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; phosphorus pentoxide; hydrazine hydrate; 1,1'-carbonyldiimidazole; calcium carbonate; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

3-bromo-5-methyl-benzoic acid (58530-13-5) → 3-(aminomethyl)-5-bromobenzonitrile (1177558-50-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / Reflux

1.2: 1 h / 20 °C

2.1: phosphorus pentoxide / chloroform / 48 h / Reflux

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 10 h / Reflux

4.1: N,N-dimethyl-formamide / 4 h / Reflux

5.1: hydrazine hydrate / ethanol / 3 h / Reflux

With N-Bromosuccinimide; phosphorus pentoxide; hydrazine hydrate; 1,1'-carbonyldiimidazole; dibenzoyl peroxide; In tetrachloromethane; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3-bromo-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzonitrile

5-bromo-1,3-xylene

3-bromo-5-methyl-benzoic acid

3-bromo-5-methylbenzonitrile

Downstream raw materials:

tert-butyl (3-bromo-5-cyanobenzyl)carbamate