Technology Process of 3-bromo-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzonitrile
There total 8 articles about 3-bromo-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phtalimide;
In
N,N-dimethyl-formamide;
for 4h;
Reflux;
- Guidance literature:
-
In
N,N-dimethyl-formamide;
for 4h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 7 h / Reflux
2.1: calcium carbonate / 1,4-dioxane; water / 16 h / Reflux
3.1: potassium permanganate / water; acetone / 1 h / Reflux
4.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / Reflux
4.2: 1 h / 20 °C
5.1: phosphorus pentoxide / chloroform / 48 h / Reflux
6.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 10 h / Reflux
7.1: N,N-dimethyl-formamide / 4 h / Reflux
With
potassium permanganate; N-Bromosuccinimide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; phosphorus pentoxide; 1,1'-carbonyldiimidazole; calcium carbonate; dibenzoyl peroxide;
In
1,4-dioxane; tetrachloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
