Ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate

Base Information

• Chemical Name: Ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate
• CAS No.: 925006-96-8
• Molecular Formula: C13H13NO4
• Molecular Weight: 247.251
• Hs Code.: 2934999090
• Mol file: 925006-96-8.mol

Synonyms:Ethyl 5-(4-methoxyphenyl);ethyl 5-(4-methoxyphenyl)-1,2-oxazole-3-carboxylate;3-Isoxazolecarboxylic acid, 5-(4-methoxyphenyl)-, ethyl ester

Chemical Property of Ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate

Chemical Property:

• Melting Point: 86-87 °C(Solv: ethanol (64-17-5))
• Boiling Point: 413.3±40.0 °C(Predicted)
• PKA: -6.21±0.38(Predicted)
• PSA: 61.56000
• Density: 1.182±0.06 g/cm3(Predicted)
• LogP: 2.52690
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-(4-Methoxyphenyl)-isoxazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 5-(4-methoxyphenyl)-isoxazole-3-carboxylate

Technology Process of Ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate

There total 16 articles about Ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl (Z)-2-fluoro-4-(4-methoxyphenyl)-4-oxobut-2-enoate → ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate (925006-96-8)

Guidance literature:

With sodium azide; In acetonitrile; at 80 ℃; for 3h; Schlenk technique;

DOI:10.1016/j.tetlet.2021.153052

Reference yield: 90.0%

BF4(1-)*C19H24N3O5(1+) → ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate (925006-96-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.5h; Green chemistry;

DOI:10.1002/jhet.1673

Reference yield: 86.0%

2-(4-methoxyphenyl)cyclopropanecarboxylic acid ethyl ester (98017-60-8) → ethyl 5-(4-methoxyphenyl)isoxazole-3-carboxylate (925006-96-8)

Guidance literature:

With trifluoroacetic acid; sodium nitrite; at 20 ℃;

DOI:10.1007/s10593-009-0315-6

upstream raw materials:

ethyl 2-chloro-2-(hydroxyimino)acetate

4-methoxyphenylacetylen

ethyl 5-(4-methoxyphenyl)-4,5-dihydroisoxazole-3-carboxylate

2-(4-methoxyphenyl)cyclopropanecarboxylic acid ethyl ester

Downstream raw materials:

C₁₁H₉NO₃

2-amino-3-cyano-7-dimethylamino-4-(5-(4-methoxyphenyl)isoxazol-3-yl)-4H-chromene

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