2-(2-broMo-1,3-thiazol-4-yl)acetonitrile

Base Information

• Chemical Name: 2-(2-broMo-1,3-thiazol-4-yl)acetonitrile
• CAS No.: 1254558-78-5
• Molecular Formula: C5H3BrN2S
• Molecular Weight: 203.062
• Mol file: 1254558-78-5.mol

Synonyms:2-(2-broMo-1,3-thiazol-4-yl)acetonitrile;2-(2-Bromothiazol-4-yl)acetonitrile

Chemical Property of 2-(2-broMo-1,3-thiazol-4-yl)acetonitrile

Chemical Property:

• PSA: 64.92000
• LogP: 1.97168
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Bromothiazol-4-yl)acetonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-broMo-1,3-thiazol-4-yl)acetonitrile

There total 2 articles about 2-(2-broMo-1,3-thiazol-4-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

sodium cyanide (773837-37-9) + 2-bromo-4-(iodomethyl)thiazole (1254558-77-4) → 2-(2-bromothiazol-4-yl)acetonitrile (1254558-78-5)

Guidance literature:

In dimethyl sulfoxide; for 0.666667h; Inert atmosphere;

Reference yield: 31.0%

potassium cyanide + 4-(chloromethyl)thiazol-2-amine hydrochloride (59608-97-8) → 2-(2-bromothiazol-4-yl)acetonitrile (1254558-78-5)

Guidance literature:

4-(chloromethyl)thiazol-2-amine hydrochloride; With sulfuric acid; sodium nitrite; In water; for 0.333333h;

With hydrogen bromide; In water; at 20 ℃; for 1h;

potassium cyanide; In N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.6b00442

Reference yield: 60.0%

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine (1160502-13-5) + 2-(2-bromothiazol-4-yl)acetonitrile (1254558-78-5) → 2-(2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)thiazol-4-yl)ethanenitrile (1254558-79-6)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 150 ℃; for 0.333333h; Microwave irradiation;

upstream raw materials:

sodium cyanide

2-bromo-4-(iodomethyl)thiazole

4-(chloromethyl)thiazol-2-amine hydrochloride

Downstream raw materials:

2-(2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-4-yl)thiazol-4-yl)ethanenitrile

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