tert-Butyl 3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxylate
• CAS No.: 1184918-34-0
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.2774
• Hs Code.: 2933990090
• Mol file: 1184918-34-0.mol

Synonyms:tert-Butyl 3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxylate;Cis-1-N-Boc-3-amino-4-(hydroxymethyl)pyrrolidine

Chemical Property of tert-Butyl 3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxylate

Chemical Property:

• PSA: 75.79000
• LogP: 0.81110

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-4-hydroxymethyl-pyrrolidine-1-carboxylicacidtert-butylester 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxylate

There total 17 articles about tert-Butyl 3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 1-benzyltetrahydro-1H-pyrrolo[3,4-c]isoxazole-5(3H)-carboxylate → (±)-cis-tert-butyl-3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate (1184918-34-0)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol;

Reference yield:

N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5) → (3S,4S)-3-amino-4-hydroxymethyl-N-t-butoxycarbonylpyrrolidine (1184918-34-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 0 °C

2: diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

3: potassium carbonate / toluene / 20 °C

4: H₂ / Pd(OH)/C / 760 Torr

With hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1128/AAC.45.9.2563-2570.2001

Reference yield:

N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5) → (3R,4R)-3-amino-4-hydroxymethyl-N-t-butoxycarbonylpyrrolidine (1184918-34-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 0 °C

2: diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

3: potassium carbonate / toluene / 20 °C

4: H₂ / Pd(OH)/C / 760 Torr

With hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1128/AAC.45.9.2563-2570.2001

upstream raw materials:

1-(2-hydroxy-1-phenyl-ethyl)-tetrahydro-pyrrolo[3,4-c]isoxazole-5-carboxylic acid tert-butyl ester

N-allyl-N-(tert-butoxycarbonyl)glycine methyl ester

N-(tert-butoxycarbonyl)glycine methyl ester

N-allyl-N-(tert-butyloxycarbonyl)-glycinal

Downstream raw materials:

(3R,4R)-4-Amino-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

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