tert-butyl allyl(2-oxoethyl)carbaMate

Base Information

• Chemical Name: tert-butyl allyl(2-oxoethyl)carbaMate
• CAS No.: 251948-88-6
• Molecular Formula: C10H17NO3
• Molecular Weight: 199.25
• Hs Code.: 2924199090
• Mol file: 251948-88-6.mol

Synonyms:tert-Butyl N-allyl-N-(2-oxoethyl)carbamate

Chemical Property of tert-butyl allyl(2-oxoethyl)carbaMate

Chemical Property:

• Boiling Point: 255.7±29.0 °C(Predicted)
• PKA: -1.72±0.70(Predicted)
• PSA: 46.61000
• Density: 1.012±0.06 g/cm3(Predicted)
• LogP: 1.60840

Purity/Quality:

98% ^*data from raw suppliers

tert-Butylallyl(2-oxoethyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl allyl(2-oxoethyl)carbaMate

There total 6 articles about tert-butyl allyl(2-oxoethyl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-allyl-N-(tert-butoxycarbonyl)glycine methyl ester (116613-80-0) → N-allyl-N-(tert-butyloxycarbonyl)-glycinal (251948-88-6)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; hexane; cyclohexane; at -78 ℃; for 1h;

Reference yield: 82.0%

(allyl-tert-butoxycarbonyl-amino)-acetic acid ethyl ester (251948-87-5) → N-allyl-N-(tert-butyloxycarbonyl)-glycinal (251948-88-6)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -80 - -65 ℃;

Reference yield:

N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5) → N-allyl-N-(tert-butyloxycarbonyl)-glycinal (251948-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 0 °C

2: diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1128/AAC.45.9.2563-2570.2001

upstream raw materials:

(allyl-tert-butoxycarbonyl-amino)-acetic acid ethyl ester

N-allyl-N-(tert-butoxycarbonyl)glycine methyl ester

N-(tert-butoxycarbonyl)glycine methyl ester

N-allylglycine ethyl ester

Downstream raw materials:

tert-butyl cis-3-amino-4-(hydroxymethyl)pyrrolidine-1-carboxylate

Refernces

• 1、 -. "SUBSTITUTED PYRROLIDINE COMPOUNDS". Paragraph 0200. . Retrieved 2016/06/01.
• 2、 Kati,Montgomery,Maring,Stoll,Giranda,Chen,Laver,Kohlbrenner,Norbeck. "Novel α- and β-amino acid inhibitors of influenza virus neuraminidase". . p. 2563 - 2570. Retrieved 2007/10/03.