(R)-Fluoxetine

Base Information

Chemical Name:(R)-Fluoxetine
CAS No.:100568-03-4
Deprecated CAS:842102-54-9,847222-29-1,849322-83-4
Molecular Formula:C₁₇H₁₈F₃NO
Molecular Weight:309.331
Hs Code.:
UNII:F279341RUQ
DSSTox Substance ID:DTXSID10872290
Nikkaji Number:J238.666F
Wikidata:Q27097676
Metabolomics Workbench ID:151604
ChEMBL ID:CHEMBL153036
Mol file:100568-03-4.mol

Synonyms:(R)-Fluoxetine;100568-03-4;(R)-(+)-fluoxetine;(+)-fluoxetine;Fluoxetine, (R)-;(3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine;(R)-Prozac;(R)-N-methyl-3-(4-trifluoromethylphenoxy)-3-phenylpropylamine;(R)-(+/-)-Fluoxetine;UNII-F279341RUQ;CHEMBL153036;CHEBI:86991;F279341RUQ;(+/-)-Fluoxetine;(R)-N-Methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine;(R)-N-methyl-3-phenyl-3-[(alpha,alpha,alpha-trifluoro-p-tolyl)oxy]propylamine;(R)-N-methyl-gamma-(4-trifluoromethylphenoxy)-3-phenylpropylamine;(R)-N-methyl-3-(4-trifluoromethylphenyloxy)-3-(phenyl)propylamine;Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (gammaR)-;RFX;R-FLUOXETINE;Lopac0_000485;BIDD:GT0614;SCHEMBL1200433;DTXSID10872290;BDBM50136166;PDSP1_001304;PDSP2_001288;AKOS015914491;CCG-204576;DB08472;NCGC00162170-01;A830402;Q27097676;Methyl-[(R)-3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine;(3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine;BENZENEPROPANAMINE, N-METHYL-.GAMMA.-(4-(TRIFLUOROMETHYL)PHENOXY)-, (.GAMMA.R)-;Benzenepropanamine,?N-methyl-.gamma.-[4-(trifluoromethyl)phenoxy]-, (.gamma.R)-

Suppliers and Price of (R)-Fluoxetine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (R)-Fluoxetine

Chemical Property:

Vapor Pressure:1.88E-06mmHg at 25°C
Boiling Point:395.1°C at 760 mmHg
Flash Point:192.8°C
PSA：21.26000
Density:1.159g/cm³
LogP:4.82590
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:309.13404868
Heavy Atom Count:22
Complexity:308

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
Isomeric SMILES:CNCC[C@H](C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F

Technology Process of (R)-Fluoxetine

There total 129 articles about (R)-Fluoxetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2,2,2-trifluoro-N-methyl-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)acetamide

: 54910-89-3,57226-07-0,100568-02-3,100568-03-4,59333-67-4
FLUOXETINE

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1039/c9ob02635e

Reference yield: 87.0%

: 42142-52-9
3-methylamino-1-phenylpropan-1-ol

: 98-56-6
4-chlorobenzotrifluoride

: 54910-89-3,57226-07-0,100568-02-3,100568-03-4,59333-67-4
FLUOXETINE

Guidance literature:: 3-methylamino-1-phenylpropan-1-ol; With sodium hydride; In dimethyl sulfoxide; at 60 ℃; for 1h; Inert atmosphere;

4-chlorobenzotrifluoride; In dimethyl sulfoxide; at 100 ℃; for 10h; Inert atmosphere;

With water; In diethyl ether; dimethyl sulfoxide;
DOI:10.1080/00397910903422518

Reference yield: 86.0%

: 42142-52-9
3-methylamino-1-phenylpropan-1-ol

: 402-45-9
4-hydroxybenzotrifluoride

: 54910-89-3,57226-07-0,100568-02-3,100568-03-4,59333-67-4
FLUOXETINE

Guidance literature:: With tributylphosphine; di-isopropyl azodicarboxylate; In dichloromethane; N,N-dimethyl acetamide; at 70 ℃; for 0.0833333h;
DOI:10.1039/c0ob00906g