Altiratinib

Base Information

Chemical Name:Altiratinib
CAS No.:1345847-93-9
Molecular Formula:C26H21F3N4O4
Molecular Weight:510.472
Hs Code.:
Mol file:1345847-93-9.mol

Synonyms:Altiratinib;N-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;Altiratinib(DCC2701);DCC-2701;DP 5164;DCC2701 (Altiratinib)

Suppliers and Price of Altiratinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Altiratinib
100mg
$ 1296.00

DC Chemicals
Altiratinib(DCC-2701) >98%
1 g
$ 2200.00

DC Chemicals
Altiratinib(DCC-2701) >98%
250 mg
$ 1200.00

DC Chemicals
Altiratinib(DCC-2701) >98%
100 mg
$ 700.00

Crysdot
Altiratinib 98+%
10mg
$ 190.00

Crysdot
Altiratinib 98+%
25mg
$ 262.00

Chemtos
Altiratinib
25 mg
$ 1100.00

ChemScene
Altiratinib 95.95%
100mg
$ 450.00

ChemScene
Altiratinib 95.95%
10mg
$ 90.00

ChemScene
Altiratinib 95.95%
5mg
$ 55.00

Total 22 raw suppliers

Chemical Property of Altiratinib

Chemical Property:

Boiling Point:763.5±60.0 °C(Predicted)
PKA:12.09±0.70(Predicted)
PSA：109.42000
Density:1.557±0.06 g/cm3(Predicted)
LogP:5.21610
Solubility.:≥21.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

Altiratinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Altiratinib

There total 10 articles about Altiratinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 6228-73-5
Cyclopropancarbamid

: 1345847-77-9
N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide

: 1345847-93-9
N-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere;

Reference yield:

: 2105-61-5
1,2,4-trifluoro-5-nitrobenzene

: 1345847-93-9
N-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / Cooling with ice; Inert atmosphere

1.2: 18 h / 20 °C

2.1: zinc; ammonium chloride / methanol / 1.5 h / 20 °C / Cooling with ice

3.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

4.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With sodium hydride; ammonium chloride; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1345847-93-9
N-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

2.2: pH 5 / Cooling with ice

3.1: thionyl chloride / 0.5 h / 60 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

5.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

With thionyl chloride; water; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;