(R)-3-[(2-Hydroxy-ethyl)-methyl-amino]-pyrrolidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(R)-3-[(2-Hydroxy-ethyl)-methyl-amino]-pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:917357-85-8
Molecular Formula:C15H22N2O3
Molecular Weight:278.351
Hs Code.:

Synonyms:1-Pyrrolidinecarboxylic acid, 3-[(2-hydroxyethyl)methylamino]-, phenylmethyl ester, (3R)-

Suppliers and Price of (R)-3-[(2-Hydroxy-ethyl)-methyl-amino]-pyrrolidine-1-carboxylic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-Benzyl3-((2-hydroxyethyl)(methyl)amino)pyrrolidine-1-carboxylate 97%
1g
$ 1198.00

Total 2 raw suppliers

Chemical Property of (R)-3-[(2-Hydroxy-ethyl)-methyl-amino]-pyrrolidine-1-carboxylic acid benzyl ester

Chemical Property:

Boiling Point:436.1±45.0 °C(Predicted)
PSA：53.01000
Density:1.19±0.1 g/cm3(Predicted)
LogP:1.25950

Purity/Quality:

98% ^*data from raw suppliers

(R)-Benzyl3-((2-hydroxyethyl)(methyl)amino)pyrrolidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (R)-3-[(2-Hydroxy-ethyl)-methyl-amino]-pyrrolidine-1-carboxylic acid benzyl ester

There total 3 articles about (R)-3-[(2-Hydroxy-ethyl)-methyl-amino]-pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.5%

: 917357-84-7
benzyl (3R)-3-[(2-ethoxy-2-oxo-ethyl)(methyl)amino]pyrrolidine-1-carboxylate

: 917357-85-8,1353979-31-3,1353999-62-8
benzyl (3R)-3-[(2-hydroxyethyl)(methyl)amino]pyrrolidine-1-carboxylate

Guidance literature:: benzyl (3R)-3-[(2-ethoxy-2-oxo-ethyl)(methyl)amino]pyrrolidine-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -40 - -10 ℃; for 1h;

With water; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 638217-49-9
benzyl (3R)-3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidine-1-carboxylate

: 917357-85-8,1353979-31-3,1353999-62-8
benzyl (3R)-3-[(2-hydroxyethyl)(methyl)amino]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; methanol / 0 - 10 °C

2: potassium carbonate / acetonitrile / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -40 - -10 °C

With hydrogenchloride; methanol; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetonitrile;

Reference yield:

: 917357-83-6
benzyl (3R)-3-(methylamino)-pyrrolidine-1-carboxylate hydrochloride

: 917357-85-8,1353979-31-3,1353999-62-8
benzyl (3R)-3-[(2-hydroxyethyl)(methyl)amino]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -40 - -10 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetonitrile;