N-ethyl-1H-indole-2-carboxamide

Base Information

Chemical Name:N-ethyl-1H-indole-2-carboxamide
CAS No.:69808-72-6
Molecular Formula:C₁₁H₁₂N₂O
Molecular Weight:188.229
Hs Code.:
DSSTox Substance ID:DTXSID60499198
Nikkaji Number:J361.163I
Wikidata:Q82349767
Mol file:69808-72-6.mol

Synonyms:N-ethyl-1H-indole-2-carboxamide;69808-72-6;SCHEMBL9397179;N-ethyl-1H-indole-2-carboxamid;DTXSID60499198;AKOS008952927

Suppliers and Price of N-ethyl-1H-indole-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-ethyl-1H-indole-2-carboxamide

Chemical Property:

Melting Point:183 °C
Boiling Point:462.8±18.0 °C(Predicted)
PKA:15.80±0.30(Predicted)
PSA：48.38000
Density:1.185±0.06 g/cm3(Predicted)
LogP:2.49240
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:188.094963011
Heavy Atom Count:14
Complexity:217

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCNC(=O)C1=CC2=CC=CC=C2N1

Technology Process of N-ethyl-1H-indole-2-carboxamide

There total 5 articles about N-ethyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: N-ethyl-1-benzyl-1H-indole-2-carboxamide

: 69808-72-6
N-Ethyl-1H-indole-2-carboxamide

Guidance literature:: With aluminium trichloride; In various solvent(s); for 2h; Ambient temperature;
DOI:10.1248/cpb.39.1152

Reference yield: 42.0%

: 1202-04-6
indole-2-carboxylic acid methyl ester

: 75-04-7,85404-22-4
ethylamine

: 69808-72-6
N-Ethyl-1H-indole-2-carboxamide

Guidance literature:: In ethanol; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00585

Reference yield:

: 17017-71-9
1-benzyl-1H-indole-2-carboxylic acid

: 69808-72-6
N-Ethyl-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / diethylphosphorocyanidate, NEt₃ / dimethylformamide / 2 h / Ambient temperature

2: 70 percent / AlCl₃ / various solvent(s) / 2 h / Ambient temperature

With aluminium trichloride; diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1152