di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate

Base Information

• Chemical Name: di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate
• CAS No.: 1464788-84-8
• Molecular Formula: C13H20ClN3O2
• Molecular Weight: 285.7698
• Hs Code.: 2933399990
• Mol file: 1464788-84-8.mol

Synonyms:di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate;N,N'-Di-Boc-2-aMino-4-chloropyriMidine;tert-Butyl tert-butyl(4-chloropyrimidin-2-yl)carbamate;Di-tert-butyl (4-chloropyrimidin-2-yl)imidodicarbonate

Chemical Property of di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate

Chemical Property:

• Boiling Point: 399.7±34.0 °C(Predicted)
• PKA: -0.87±0.10(Predicted)
• PSA: 81.62000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 3.80660

Purity/Quality:

99%, ^*data from raw suppliers

Di-tert-butyl(4-Chloropyrimidin-2-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate

There total 4 articles about di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-4-chloropyrimidine (3993-78-0) → 4-chloro-2-amino(bis-carbamate)pyrimidine (1464788-84-8)

Guidance literature:

2-amino-4-chloropyrimidine; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

di-tert-butyl dicarbonate; In dichloromethane;

Reference yield: 44.8%

di-tert-butyl dicarbonate (24424-99-5) + tert-butyl (4-chlopropyrimidin-2-yl)carbamate (629645-55-2) → 4-chloro-2-amino(bis-carbamate)pyrimidine (1464788-84-8)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-chloro-2-amino(bis-carbamate)pyrimidine (1464788-84-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 4 h / 65 - 85 °C

2: trichlorophosphate; N,N-dimethyl-aniline / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: dmap / tetrahydrofuran / 20 °C

With pyridine; dmap; N,N-dimethyl-aniline; trichlorophosphate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

2-amino-4-chloropyrimidine

tert-butyl (4-chlopropyrimidin-2-yl)carbamate

tert-butyl (4-hydroxypyrimidin-2-yl)carbamate

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