tert-Butyl (4-chloropyrimidin-2-yl)carbamate

Base Information

• Chemical Name: tert-Butyl (4-chloropyrimidin-2-yl)carbamate
• CAS No.: 629645-55-2
• Molecular Formula: C₉H₁₂ClN₃O₂
• Molecular Weight: 229.666
• DSSTox Substance ID: DTXSID201216555
• Nikkaji Number: J1.923.283B
• Mol file: 629645-55-2.mol

Synonyms:629645-55-2;tert-Butyl (4-chloropyrimidin-2-yl)carbamate;Tert-butyl N-(4-chloropyrimidin-2-yl)carbamate;CARBAMICACID, (4-CHLORO-2-PYRIMIDINYL)-, 1,1-DIMETHYLETHYL ESTER (9CI);SCHEMBL17518970;DTXSID201216555;MFCD13195506;SB59753;PS-18625;t-Butyl (4-chloropyrimidin-2-yl)carbamate;tert-Butyl(4-chloropyrimidin-2-yl)carbamate;EN300-3221576;A868296;1,1-Dimethylethyl N-(4-chloro-2-pyrimidinyl)carbamate;N-(4-Chloro-2-pyrimidinyl)carbamic acid tert-butyl ester

Chemical Property of tert-Butyl (4-chloropyrimidin-2-yl)carbamate

Chemical Property:

• PSA: 64.11000
• LogP: 2.55000
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 229.0618043
• Heavy Atom Count: 15
• Complexity: 230

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(4-chloropyrimidin-2-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1=NC=CC(=N1)Cl

Technology Process of tert-Butyl (4-chloropyrimidin-2-yl)carbamate

There total 2 articles about tert-Butyl (4-chloropyrimidin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tert-butyl (4-hydroxypyrimidin-2-yl)carbamate (629645-53-0) → tert-butyl (4-chlopropyrimidin-2-yl)carbamate (629645-55-2)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1248/cpb.51.975

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-chlopropyrimidin-2-yl)carbamate (629645-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / pyridine / 4 h / 85 °C

2: 75 percent / POCl₃; N,N-dimethylaniline / CH₂Cl₂ / 2 h / 20 °C

With pyridine; N,N-dimethyl-aniline; trichlorophosphate; In dichloromethane;

DOI:10.1248/cpb.51.975

Reference yield: 44.8%

di-tert-butyl dicarbonate (24424-99-5) + tert-butyl (4-chlopropyrimidin-2-yl)carbamate (629645-55-2) → 4-chloro-2-amino(bis-carbamate)pyrimidine (1464788-84-8)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

tert-butyl (4-hydroxypyrimidin-2-yl)carbamate

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl [4-acetylpyrimidin-2-yl]carbamate

tert-butyl 4-(N-phenylethanehydrazonoyl)pyrimidin-2-ylcarbamate

t-butyl 4-(N-(4-bromophenyl)ethanehydrazonoyl)pyrimidin-2-ylcarbamate

4-chloro-2-amino(bis-carbamate)pyrimidine