2-(BroMoMethyl)-5-(trifluoroMethyl)pyridine

Base Information

• Chemical Name: 2-(BroMoMethyl)-5-(trifluoroMethyl)pyridine
• CAS No.: 1000773-62-5
• Molecular Formula: C7H5BrF3N
• Molecular Weight: 240.023
• Mol file: 1000773-62-5.mol

Synonyms:2-(BroMoMethyl)-5-(trifluoroMethyl)pyridine

Chemical Property of 2-(BroMoMethyl)-5-(trifluoroMethyl)pyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.99530
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Bromomethyl)-5-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(BroMoMethyl)-5-(trifluoroMethyl)pyridine

There total 3 articles about 2-(BroMoMethyl)-5-(trifluoroMethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-hydroxymethyl-5-trifluoromethylpyridine (31181-84-7) → 2-(bromomethyl)-5-(trifluoromethyl)pyridine (1000773-62-5)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

2‐iodo‐5‐(trifluoromethyl)pyridine (100366-75-4) → 2-(bromomethyl)-5-(trifluoromethyl)pyridine (1000773-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / toluene; hexane / 0.25 h / -78 °C

1.2: 1 h / -78 °C

1.3: -78 - 20 °C

2.1: phosphorus tribromide / dichloromethane / 3 h / 0 - 20 °C

With n-butyllithium; phosphorus tribromide; In hexane; dichloromethane; toluene;

Reference yield:

5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester (124236-37-9) → 2-(bromomethyl)-5-(trifluoromethyl)pyridine (1000773-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

2: phosphorus tribromide / dichloromethane / 3 h / 20 °C

With methanol; sodium tetrahydroborate; phosphorus tribromide; In dichloromethane;

upstream raw materials:

2-hydroxymethyl-5-trifluoromethylpyridine

2‐iodo‐5‐(trifluoromethyl)pyridine

5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester

Downstream raw materials:

tert-butyl (3R)-3-(4-([5-(trifluoromethyl)pyridin-2-yl]methoxy)phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Refernces

• 1、 -. "Micromolecular compound with anti-inflammatory activity, and preparation method and drug application of micromolecular compound". Paragraph 0105; 0106; 0107. . Retrieved 2017/08/31.
• 2、 -. "1-OXA-8-AZASPIRO [4, 5 ] DECANE- 8 -CARBOXAMIDE COMPOUNDS AS FAAH INHIBITORS". Page/Page column 78. . Retrieved 2010/07/10.