2-Iodo-5-trifluoromethylpyridine

Base Information

• Chemical Name: 2-Iodo-5-trifluoromethylpyridine
• CAS No.: 100366-75-4
• Molecular Formula: C6H3F3IN
• Molecular Weight: 272.996
• Hs Code.: 2933399090
• Mol file: 100366-75-4.mol

Synonyms:2-Iodo-5-(trifluoromethyl)pyridine;

Chemical Property of 2-Iodo-5-trifluoromethylpyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Vapor Pressure: 0.213mmHg at 25°C
• Melting Point: 82-83 °C(Solv: hexane (110-54-3))
• Refractive Index: 1.523
• Boiling Point: 215.722 °C at 760 mmHg
• PKA: -0.58±0.10(Predicted)
• Flash Point: 84.266 °C
• PSA: 12.89000
• Density: 1.975 g/cm³
• LogP: 2.70500
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Iodo-5-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Iodo-5-trifluoromethylpyridine

There total 4 articles about 2-Iodo-5-trifluoromethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ 2‐iodo‐5‐(trifluoromethyl)pyridine (100366-75-4)

Guidance literature:

With copper(l) iodide; sodium iodide; In 1,4-dioxane; for 0.166667h;

With N,N`-dimethylethylenediamine; In 1,4-dioxane; at 130 ℃; for 18h;

Reference yield: 82.0%

2-chloro-5-trifluoromethylpyridine (52334-81-3) → 2‐iodo‐5‐(trifluoromethyl)pyridine (100366-75-4)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In various solvent(s); for 75h; Heating;

DOI:10.1002/ejoc.200390215

Reference yield: 39.0%

2,6-dichloro-3-(trifluoromethyl)pyridine (55304-75-1) → 2‐iodo‐5‐(trifluoromethyl)pyridine (100366-75-4)

Guidance literature:

With hydrogen iodide; sodium iodide; for 24h; Heating;

DOI:10.1021/jo00356a043

upstream raw materials:

2,6-dichloro-3-(trifluoromethyl)pyridine

2-chloro-5-trifluoromethylpyridine

acetyl chloride

Downstream raw materials:

C₁₈H₁₇F₃N₂

2-hydroxymethyl-5-trifluoromethylpyridine

2-(bromomethyl)-5-(trifluoromethyl)pyridine

5-(trifluoromethyl)pyridine-2-carbaldehyde

Refernces

• 1、 -. "Oxadiazolopyridine Derivates for Use as Ghrelin O-Acyl Transferase (GOAT) Inhibitors". Paragraph 0249-0253; 0254-0258. . Retrieved 2018/03/01.
• 2、 -. "Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof". . . Retrieved 2008/06/13.