6-Boc-2-aMino-6-aza-spiro...

Base Information

• Chemical Name: 6-Boc-2-aMino-6-aza-spiro...
• CAS No.: 1239319-94-8
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.319
• Hs Code.: 2933990090
• Mol file: 1239319-94-8.mol

Synonyms:6-Boc-2-aMino-6-aza-spiro...;6-Boc-2-aMino-6-aza-spiro[3.4]octane;2-AMino-6-aza-spiro[3.4]octane-6-carboxylic acid tert-butyl ester;tert-butyl 2-aMino-7-azaspiro[3.4]octane-7-carboxylate;tert-Butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate

Chemical Property of 6-Boc-2-aMino-6-aza-spiro...

Chemical Property:

• Boiling Point: 318.8±35.0 °C(Predicted)
• PKA: 10.60±0.20(Predicted)
• PSA: 55.56000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 2.37290
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-6-aza-spiro[3.4]octane-6-carboxylicacidtert-butylester 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 2-Amino-6-azaspiro[3.4]octane-6-carboxylate is a synthesis reagent, a pharmaceutical intermediate and a useful research chemical for biological studies.

Technology Process of 6-Boc-2-aMino-6-aza-spiro...

There total 4 articles about 6-Boc-2-aMino-6-aza-spiro... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-azido-6-azaspiro[3.4]octane-6-carboxylate (1239319-93-7) → tert-butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate (1239319-94-8)

Guidance literature:

With hydrogen; Lindlar catalyst; In ethanol; at 20 ℃; for 5h; under 1034.32 Torr;

Reference yield:

2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester (1239319-91-5) → tert-butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate (1239319-94-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1.5 h / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 12 h / Inert atmosphere; Reflux

3: hydrogen / Lindlar catalyst / ethanol / 5 h / 20 °C / 1034.32 Torr

With sodium azide; hydrogen; triethylamine; Lindlar catalyst; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester (203661-71-6) → tert-butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate (1239319-94-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / 1.5 h / 0 - 20 °C

2: triethylamine / dichloromethane / 1.5 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 12 h / Inert atmosphere; Reflux

4: hydrogen / Lindlar catalyst / ethanol / 5 h / 20 °C / 1034.32 Torr

With methanol; sodium tetrahydroborate; sodium azide; hydrogen; triethylamine; Lindlar catalyst; In ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester

6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester

tert-butyl 2-[(methylsulfonyl)oxy]-6-azaspiro[3.4]octane-6-carboxylate

tert-butyl 2-azido-6-azaspiro[3.4]octane-6-carboxylate

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