6-Boc-2-oxo-6-aza-spiro[3.4]octane

Base Information

• Chemical Name: 6-Boc-2-oxo-6-aza-spiro[3.4]octane
• CAS No.: 203661-71-6
• Molecular Formula: C₁₂H₁₉NO₃
• Molecular Weight: 225.288
• Hs Code.: 2933998090
• Mol file: 203661-71-6.mol

Synonyms:6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester

Chemical Property of 6-Boc-2-oxo-6-aza-spiro[3.4]octane

Chemical Property:

• Boiling Point: 331.8±35.0 °C(Predicted)
• PKA: -0.80±0.20(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

96% ^*data from raw suppliers

tert-butyl2-oxo-6-azaspiro[3.4]octane-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Boc-2-oxo-6-aza-spiro[3.4]octane

There total 2 articles about 6-Boc-2-oxo-6-aza-spiro[3.4]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl 1,1-dichloro-2-oxo-6-azaspiro[3.4]octane-6-carboxylate (1558037-99-2) → 6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester (203661-71-6)

Guidance literature:

With ammonium chloride; zinc; In methanol; at 20 ℃; for 3h;

Reference yield:

tert-butyl 3-methylidenepyrrolidine-1-carboxylate (114214-71-0) → 6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester (203661-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc/copper couple / diethyl ether; 1,2-dimethoxyethane / 48 h / 10 - 20 °C / Inert atmosphere

2: zinc; ammonium chloride / methanol / 8 h / 20 °C

With zinc/copper couple; ammonium chloride; zinc; In methanol; 1,2-dimethoxyethane; diethyl ether;

Reference yield: 72.0%

2-(4-amino-2-fluorophenyl)acetonitrile (180146-78-5) + 6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester (203661-71-6) → C20H26FN3O2

Guidance literature:

With methanol; nido-decaborane; at 20 ℃; for 8h;

upstream raw materials:

tert-butyl 3-methylidenepyrrolidine-1-carboxylate

tert-butyl 1,1-dichloro-2-oxo-6-azaspiro[3.4]octane-6-carboxylate

Downstream raw materials:

2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester

tert-butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate

tert-butyl 2-aminomethyl-6-azaspiro[3.4]octane-6-carboxylate

C₁₉H₂₇NO₅S

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