N-BOC-6-azaspiro[3.4]octan-2-ol

Base Information

• Chemical Name: N-BOC-6-azaspiro[3.4]octan-2-ol
• CAS No.: 1239319-91-5
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.304
• Hs Code.: 2933990090
• Mol file: 1239319-91-5.mol

Synonyms:tert-butyl 2-hydroxy-6-azaspiro[3.4]octane-6-carboxylate;N-BOC-6-azaspiro[3.4]octan-2-ol;

Chemical Property of N-BOC-6-azaspiro[3.4]octan-2-ol

Chemical Property:

• Boiling Point: 338℃
• Flash Point: 156℃
• PSA: 49.77000
• Density: 1.14
• LogP: 1.70620
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl2-Hydroxy-6-azaspiro[3.4]octane-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-6-azaspiro[3.4]octan-2-ol

There total 4 articles about N-BOC-6-azaspiro[3.4]octan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester (203661-71-6) → 2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester (1239319-91-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

Reference yield:

tert-butyl 3-methylidenepyrrolidine-1-carboxylate (114214-71-0) → 2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester (1239319-91-5)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc/copper couple / diethyl ether; 1,2-dimethoxyethane / 48 h / 10 - 20 °C / Inert atmosphere

2: zinc; ammonium chloride / methanol / 8 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 20 °C

With sodium tetrahydroborate; zinc/copper couple; ammonium chloride; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether;

Reference yield:

tert-butyl 1,1-dichloro-2-oxo-6-azaspiro[3.4]octane-6-carboxylate (1558037-99-2) → 2-hydroxy-7-azaspiro[3.4]octane-7-carboxylic acid tert-butyl ester (1239319-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; ammonium chloride / methanol / 8 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / 6 h / 0 - 20 °C

With sodium tetrahydroborate; ammonium chloride; zinc; In tetrahydrofuran; methanol;

upstream raw materials:

6-azaspiro[3.4]octane-6-carboxylic acid,2-oxo-,1,1-dimethylethyl ester

tert-butyl 3-methylidenepyrrolidine-1-carboxylate

tert-butyl 1,1-dichloro-2-oxo-6-azaspiro[3.4]octane-6-carboxylate

Downstream raw materials:

tert-butyl 2-amino-6-azaspiro[3.4]octane-6-carboxylate

tert-butyl 2-aminomethyl-6-azaspiro[3.4]octane-6-carboxylate

C₁₉H₂₇NO₅S

C₁₉H₂₇NO₅S