2-(4-CYANO-PHENYL)-N-BOC-ETHYLAMINE

Base Information

• Chemical Name: 2-(4-CYANO-PHENYL)-N-BOC-ETHYLAMINE
• CAS No.: 172348-86-6
• Molecular Formula: C14H18N2O2
• Molecular Weight: 246.309
• Hs Code.: 2926909090
• Mol file: 172348-86-6.mol

Synonyms:2-(4-CYANO-PHENYL)-N-BOC-ETHYLAMINE

Chemical Property of 2-(4-CYANO-PHENYL)-N-BOC-ETHYLAMINE

Chemical Property:

• PSA: 62.12000
• LogP: 3.01638
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl4-cyanophenethylcarbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-CYANO-PHENYL)-N-BOC-ETHYLAMINE

There total 19 articles about 2-(4-CYANO-PHENYL)-N-BOC-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(4-cyanophenyl)propionic acid (42287-94-5) + tert-butyl alcohol (75-65-0) → tert-butyl N-[2-(4-cyanophenyl)ethyl]carbamate (172348-86-6)

Guidance literature:

With TEA; diphenyl-phosphinic acid; Heating;

DOI:10.1016/j.bmcl.2004.07.054

Reference yield: 88.9%

dicyanozinc (557-21-1) + t-butyl 2-(4-bromophenyl)ethylcarbamate (120157-97-3) → tert-butyl N-[2-(4-cyanophenyl)ethyl]carbamate (172348-86-6)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 150 ℃; for 0.333333h; Microwave irradiation;

Reference yield: 86.0%

4-Cyanochlorobenzene (623-03-0) + t-butyl N-vinylcarbamate (7150-72-3) → tert-butyl N-[2-(4-cyanophenyl)ethyl]carbamate (172348-86-6)

Guidance literature:

With Cyclohexanethiol; 10-phenyl-10H-phenothiazine; sodium formate; In water; dimethyl sulfoxide; at 23 ℃; for 16h; regioselective reaction; Irradiation; Inert atmosphere; Sealed tube; Cooling;

DOI:10.1021/jacs.9b01077

upstream raw materials:

(4-cyanophenyl)propionic acid

tert-butyl alcohol

4-bromobenzenecarbonitrile

t-butyl N-vinylcarbamate

Downstream raw materials:

tert-butyl {2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl}carbamate

2-[4-(4,5-dihydro-1H-imidazol-2-yl)-phenyl]-ethylamine

N-[2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl]-2-[2-[(6-methoxynaphthalen-2-yl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]acetamide

tert-butyl (3-chloropropyl)-[2-(4-cyanophenyl)ethyl]carbamate

Refernces

• 1、 Hendy, Cecilia M.,Smith, Gavin C.,Xu, Zihao,Lian, Tianquan,Jui, Nathan T.. "Radical Chain Reduction via Carbon Dioxide Radical Anion (CO2?-)". supporting information. p. 8987 - 8992. Retrieved 2021/07/01.
• 2、 -. "COMPOUNDS AND USES THEREOF". Page/Page column 117; 224. . Retrieved 2021/10/15.