1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE

Base Information

• Chemical Name: 1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE
• CAS No.: 1035173-74-0
• Molecular Formula: C12H14ClNO4S
• Molecular Weight: 303.766
• Hs Code.: 2933990090
• Mol file: 1035173-74-0.mol

Synonyms:1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE;3-CHLOROSULFONYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER;Benzyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-(chlorosulfonyl)-, phenylmethyl ester

Chemical Property of 1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE

Chemical Property:

• Boiling Point: 442.6±44.0 °C(Predicted)
• PKA: -4?+-.0.40(Predicted)
• PSA: 72.06000
• Density: 1.43±0.1 g/cm3(Predicted)
• LogP: 2.98480
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Benzyl3-(Chlorosulfonyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Benzyl 3-(Chlorosulfonyl)pyrrolidine-1-carboxylate is used as a reactant in the preparation of sulfonamide analogs of phosphatidylinositol 3-kinase inhibitor ZSTK474.

Technology Process of 1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE

There total 4 articles about 1-CBZ-3-CHLOROSULFONYL-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 3-(acetylthio)pyrrolidine-1-carboxylate (930299-97-1) → benzyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate (1035173-74-0)

Guidance literature:

With water; chlorine; In dichloromethane; at 0 ℃; for 3.5h;

Reference yield:

(R)-3-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid,phenylmethyl ester (138232-44-7) → benzyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate (1035173-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 - 80 °C

2: water; chlorine / dichloromethane / 0 - 10 °C

With water; chlorine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1055/s-0030-1260223

Reference yield:

benzyl 3-hydroxypyrrolidine-1-carboxylate (95656-88-5) → benzyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate (1035173-74-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 10 - 80 °C

3: water; chlorine / dichloromethane / 0 - 10 °C

With water; chlorine; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1055/s-0030-1260223

upstream raw materials:

benzyl 3-(acetylthio)pyrrolidine-1-carboxylate

(R)-3-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid,phenylmethyl ester

benzyl chloroformate

benzyl 3-hydroxypyrrolidine-1-carboxylate

Downstream raw materials:

(RS)-benzyl 3-(N-(tert-butoxycarbonyl)-N-(5-(4-(4-cyanophenyl)piperidine-1-carbonyl)-2-methylphenyl)sulfamoyl)pyrrolidine-1-carboxylate

benzyl 3-[(methylamino)sulfonyl]-1-pyrrolidinecarboxylate

3-[[[2-(dimethylamino)ethyl]amino]sulfonyl]-1-pyrrolidinecarboxylate