3-HYDROXY-1-N-CBZ-PYRROLIDINE

Base Information

• Chemical Name: 3-HYDROXY-1-N-CBZ-PYRROLIDINE
• CAS No.: 95656-88-5
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Hs Code.: 2933990090
• Mol file: 95656-88-5.mol

Synonyms:3-Hydroxypyrrolidine-1-carboxylicacid benzyl ester;Benzyl 3-hydroxy-1-pyrrolidinecarboxylate;N-Benzyloxycarbonyl-3-hydroxypyrrolidine;N-Benzyloxycarbonyl-3-pyrrolidinol;

Chemical Property of 3-HYDROXY-1-N-CBZ-PYRROLIDINE

Chemical Property:

• Vapor Pressure: 3.75E-06mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 370.7 °C at 760 mmHg
• PKA: 14.72±0.20(Predicted)
• Flash Point: 178 °C
• PSA: 49.77000
• Density: 1.263 g/cm³
• LogP: 1.32770
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Benzyl3-Hydroxypyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-HYDROXY-1-N-CBZ-PYRROLIDINE

There total 16 articles about 3-HYDROXY-1-N-CBZ-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

pyrrolidin-3-ol (40499-83-0) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 3-hydroxypyrrolidine-1-carboxylate (95656-88-5)

Guidance literature:

With sodium carbonate; In diethyl ether; water;

DOI:10.1039/b700215g

Reference yield: 95.0%

pyrrolidin-3-ol (40499-83-0) + phenyl chloroformate (1885-14-9) → benzyl 3-hydroxypyrrolidine-1-carboxylate (95656-88-5)

Guidance literature:

Reference yield: 94.0%

pyrrolidin-3-ol (40499-83-0) + phenyl chloroacetate (620-73-5) → benzyl 3-hydroxypyrrolidine-1-carboxylate (95656-88-5)

Guidance literature:

With sodium hydroxide; In diethyl ether; for 3h;

upstream raw materials:

pyrrolidin-3-ol

phenyl chloroacetate

1-carboxybenzyl-3-pyrrolidine

(R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid

Downstream raw materials:

benzyl 3-oxopyrrolidine-1-carboxylate

(S)-3-(acetyloxy)-1-pyrrolidinecarboxylic acid, phenylmethyl ester

2,3-dihydro-pyrrole-1-carboxylic acid benzyl ester

(S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester