138232-44-7

Basic information

• Product Name: 1-((BENZYLOXY)CARBONYL)PYRROLIDIN-3-YL METHANESULFONATE
• Synonyms: 1-((BENZYLOXY)CARBONYL)PYRROLIDIN-3-YL METHANESULFONATE
• CAS NO: 138232-44-7
• Molecular Formula: C₁₃H₁₇NO₅S
• Molecular Weight: 299.34278
• Mol File: 138232-44-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-((BENZYLOXY)CARBONYL)PYRROLIDIN-3-YL METHANESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((BENZYLOXY)CARBONYL)PYRROLIDIN-3-YL METHANESULFONATE(138232-44-7)
• EPA Substance Registry System: 1-((BENZYLOXY)CARBONYL)PYRROLIDIN-3-YL METHANESULFONATE(138232-44-7)

Safety Data

• Hazardous Substances Data: 138232-44-7(Hazardous Substances Data)

Usage

General Description

1-((Benzyloxy)carbonyl)pyrrolidin-3-yl methanesulfonate is a chemical compound commonly used in organic synthesis and medicinal chemistry. It is a derivative of pyrrolidine, a heterocyclic organic compound, and contains a benzyloxy carbonyl group and a methanesulfonate group. 1-((BENZYLOXY)CARBONYL)PYRROLIDIN-3-YL METHANESULFONATE is often utilized as a protecting group for the amine functionality in organic chemistry reactions, as well as a building block for the synthesis of various pharmaceuticals and bioactive molecules. Its usage in medicinal chemistry often involves the modification of the pyrrolidine ring to enhance the pharmacological properties of drug candidates. Additionally, the methanesulfonate group can act as a leaving group in chemical reactions, facilitating the formation of specific chemical bonds.

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 95656-88-5 benzyl 3-hydroxypyrrolidine-1-carboxylate 
• 501-53-1 benzyl chloroformate 
• 130312-02-6 benzyl 3-oxopyrrolidine-1-carboxylate 

Downstream Products

• 1035173-74-0 benzyl 3-(chlorosulfonyl)pyrrolidine-1-carboxylate 
• 930299-97-1 benzyl 3-(acetylthio)pyrrolidine-1-carboxylate 
• 1196044-28-6 C₁₇H₂₁NO₆ 
• 188846-99-3 (+/-)-3-cyanopyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF

A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.

Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity

Wogonin, a natural product isolated from the plant Scutellaria baicalensis, has been shown to be a potent and selective inhibitor of CDK9. With the purpose of investigating the activity and selectivity of this chemical scaffold, several series of wogonin derivatives were prepared and screened for CDK9 inhibition and cellular antiproliferative activity. Among these compounds, the drug-like compound 51 showed potent activity against CDK9 (IC50 = 19.9 nM) and MV4-11 cell growth (IC50 = 20 nM). In addition, compound 51 showed much improved physicochemical properties, such as water solubility, compared with the parent compound wogonin. The follow-up studies showed that the compound 51 is selective toward CDK9-overexpressing cancer cells over normal cells. Preliminary mechanism studies on the anticancer effect indicated that 51 inhibited the proliferation of MV4-11 cells via caspase-dependent apoptosis. In addition, highlighted compound 51 showed significant antitumor activity in mouse acute myeloid leukemia (AML) models without producing apparent toxic effects in vivo, which gave us a new tool for further investigation of CDK9-targeted inhibitor as a potential antitumor drug especially for AML.

A library of conformationally restricted saturated heterocyclic sulfonyl chlorides

An approach to the synthesis of conformationally restricted saturated heterocyclic sulfonyl chlorides is described. Being guided by the principle of diversity-oriented conformational restriction, a mini-library of saturated heterocyclic sulfonyl chlorides