4-(diisopropylcarbaMoyl)-2-ethoxypyridin-3-ylboronic acid

Base Information

• Chemical Name: 4-(diisopropylcarbaMoyl)-2-ethoxypyridin-3-ylboronic acid
• CAS No.: 1131735-94-8
• Molecular Formula: C14H23BN2O4
• Molecular Weight: 294.159
• Hs Code.: 2933399090
• Mol file: 1131735-94-8.mol

Synonyms:4-(diisopropylcarbaMoyl)-2-ethoxypyridin-3-ylboronic acid

Chemical Property of 4-(diisopropylcarbaMoyl)-2-ethoxypyridin-3-ylboronic acid

Chemical Property:

• PSA: 82.89000
• LogP: 0.41910
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(4-(Diisopropylcarbamoyl)-2-ethoxypyridin-3-yl)boronicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(diisopropylcarbaMoyl)-2-ethoxypyridin-3-ylboronic acid

There total 3 articles about 4-(diisopropylcarbaMoyl)-2-ethoxypyridin-3-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 2-ethoxy-N,N-diisopropylisonicotinamide (1131735-93-7) → {4-[(diisopropylamino)carbonyl]-2-ethoxypyridin-3-yl}boronic acid (1131735-94-8)

Guidance literature:

2-ethoxy-N,N-diisopropylisonicotinamide; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.333333h;

Trimethyl borate; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h;

With hydrogenchloride; water; ammonium chloride; In tetrahydrofuran; cyclohexane; at 0 - 20 ℃; for 1h;

Reference yield:

2-ethoxyisonicotinic acid (91940-86-2) → {4-[(diisopropylamino)carbonyl]-2-ethoxypyridin-3-yl}boronic acid (1131735-94-8)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane

2: triethylamine / dichloromethane

3: sec.-butyllithium / tetrahydrofuran / -78 °C

With oxalyl dichloride; sec.-butyllithium; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2014.02.011

Reference yield:

2-ethoxynicotinic acid → {4-[(diisopropylamino)carbonyl]-2-ethoxypyridin-3-yl}boronic acid (1131735-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: sec.-butyllithium / tetrahydrofuran / -78 °C

With sec.-butyllithium; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2014.02.011

upstream raw materials:

Trimethyl borate

2-ethoxy-N,N-diisopropylisonicotinamide

2-ethoxyisonicotinic acid

Downstream raw materials:

3-(2-amino-5-bromophenyl)-2-ethoxy-N,N-diisopropylisonicotinamide

3-(2-amino-5-fluorophenyl)-2-ethoxy-N,N-diisopropylisonicotinamide

6-{[2,6-dichloro-4-(trifluoromethoxy)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

6-{[2,6-dichloro-4-(difluoroacetyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

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