2-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-5-fluorobenzene-1-sulfonyl chloride

Base Information

Chemical Name:2-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-5-fluorobenzene-1-sulfonyl chloride
CAS No.:1341200-87-0
Molecular Formula:C₁₁H₇Cl₃FN₃O₂S
Molecular Weight:0
Hs Code.:
Mol file:1341200-87-0.mol

Synonyms:2-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-5-fluorobenzene-1-sulfonyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-5-fluorobenzene-1-sulfonyl chloride

Chemical Property:

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Technology Process of 2-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-5-fluorobenzene-1-sulfonyl chloride

There total 2 articles about 2-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-5-fluorobenzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1341200-86-9
2,5-dichloro-N-(4-fluorophenyl)-N-methylpyrimidin-4-amine

: 1341200-87-0
2-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-5-fluorobenzene-1-sulfonyl chloride

Guidance literature:: With chlorosulfonic acid; for 4h;
DOI:10.1021/ml200198x

Reference yield:

: 459-59-6
4-fluoro-N-methylaniline

: 1341200-87-0
2-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-5-fluorobenzene-1-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 12 h / Reflux

2: chlorosulfonic acid / 4 h

With chlorosulfonic acid; N-ethyl-N,N-diisopropylamine; In isopropyl alcohol;
DOI:10.1021/ml200198x