3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride

Base Information

Chemical Name:3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride
CAS No.:210688-56-5
Molecular Formula:C22H27N3O.2HCl
Molecular Weight:422
Hs Code.:
Mol file:210688-56-5.mol

Synonyms:3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride;PD 168568 dihydrochloride

Suppliers and Price of 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PD 168568 dihydrochloride
10mg
$ 409.00

TRC
PD168568
25mg
$ 230.00

Tocris
PD168568dihydrochloride ≥98%(HPLC)
50
$ 616.00

Tocris
PD168568dihydrochloride ≥98%(HPLC)
10
$ 147.00

ApexBio Technology
PD168568dihydrochloride
10mg
$ 257.00

ApexBio Technology
PD168568dihydrochloride
50mg
$ 1082.00

American Custom Chemicals Corporation
PD 168568 DIHYDROCHLORIDE 95.00%
5MG
$ 503.56

Total 3 raw suppliers

Chemical Property of 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride

Chemical Property:

PSA：35.58000
LogP:5.23590
Storage Temp.:Desiccate at RT

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

PD 168568 dihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses PD 168568 is a selective D4 receptor affinity.

Technology Process of 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride

There total 7 articles about 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-onedihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 584-08-7
potassium carbonate

: 1014-05-7
1-(3,4-dimethylphenyl)piperazine

: 210688-55-4
1,3-dihydro-3-(2-tosylethyl)-2H-isoindol-1-one

: 210688-56-5
PD 168568

Guidance literature:: In water; acetonitrile;

Reference yield:

: 1014-05-7
1-(3,4-dimethylphenyl)piperazine

: 210688-55-4
1,3-dihydro-3-(2-tosylethyl)-2H-isoindol-1-one

: 210688-56-5
PD 168568

Guidance literature:: With potassium carbonate; In acetonitrile; at 82 ℃;
DOI:10.1016/S0960-894X(98)00252-2

Reference yield:

: 3849-22-7
(3-oxo-2,3-dihydro-1H-isoindol-1-yl)-acetic acid

: 210688-56-5
PD 168568

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 2.) DMF

2: NaBH₄ / methanol / Ambient temperature

3: TEA / CH₂Cl₂

4: K₂CO₃ / acetonitrile / 82 °C

With sodium tetrahydroborate; TEA; sodium hydride; potassium carbonate; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0960-894X(98)00252-2