4-Piperidinyl Phthalimide

Base Information

• Chemical Name: 4-Piperidinyl Phthalimide
• CAS No.: 78048-99-4
• Molecular Formula: C₁₃H₁₄N₂O₂
• Molecular Weight: 230.266
• Mol file: 78048-99-4.mol

Synonyms:4-Piperidinyl Phthalimide

Chemical Property of 4-Piperidinyl Phthalimide

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinyl Phthalimide

There total 1 articles about 4-Piperidinyl Phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 2-(piperidin-4-yl)isoindoline-1,3-dione (78048-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 90 percent / N,N-dimethylacetamide / 8 h / Heating

2.1: 1,2-dichloro-ethane / 3 h / Heating

2.2: 82 percent / MeOH / 2 h / Heating

With N,N-dimethyl acetamide; In 1,2-dichloro-ethane;

DOI:10.1021/jo001281w

Reference yield: 30.0%

2-(piperidin-4-yl)isoindoline-1,3-dione (78048-99-4) + 1-bromo-4-(5,5-dimethyl-1,3-dioxan-2-yl)benzene (105114-53-2) → 1-[4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl]-4-phthalimidopiperidine (321733-39-5)

Guidance literature:

With potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 80 ℃; for 6h;

DOI:10.1021/jo001281w

Reference yield:

5-(4-chloro-3-nitrophenyl)-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one (132442-88-7) + 2-(piperidin-4-yl)isoindoline-1,3-dione (78048-99-4) → 5-[5-(4-Phthalimido-piperidin-1-yl)-3-nitro-phenyl]-6-methyl-3H,6H-1,3,4-thiadiazin-2-one

Guidance literature:

With triethylamine; In 1,4-dioxane; water;

upstream raw materials:

phthalic anhydride

Downstream raw materials:

1-[4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl]-4-phthalimidopiperidine

1-(4-formylphenyl)-4-phthalimidopiperidine

Refernces