1-(4-formylphenyl)-4-phthalimidopiperidine

Base Information

• Chemical Name: 1-(4-formylphenyl)-4-phthalimidopiperidine
• CAS No.: 321733-40-8
• Molecular Formula: C₂₀H₁₈N₂O₃
• Molecular Weight: 334.375
• Mol file: 321733-40-8.mol

Synonyms:1-(4-formylphenyl)-4-phthalimidopiperidine

Chemical Property of 1-(4-formylphenyl)-4-phthalimidopiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-formylphenyl)-4-phthalimidopiperidine

There total 5 articles about 1-(4-formylphenyl)-4-phthalimidopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-[4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl]-4-phthalimidopiperidine (321733-39-5) → 1-(4-formylphenyl)-4-phthalimidopiperidine (321733-40-8)

Guidance literature:

With sulfuric acid; trifluoroacetic acid; at 20 ℃; for 2h;

DOI:10.1021/jo001281w

Reference yield:

phthalic anhydride (85-44-9) → 1-(4-formylphenyl)-4-phthalimidopiperidine (321733-40-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 90 percent / N,N-dimethylacetamide / 8 h / Heating

2.1: 1,2-dichloro-ethane / 3 h / Heating

2.2: 82 percent / MeOH / 2 h / Heating

3.1: 30 percent / BINAP; t-BuOK / Pd₂(dba)3 / toluene / 6 h / 80 °C

4.1: 86 percent / aq.H₂SO₄; trifluoroacetic acid / 2 h / 20 °C

With N,N-dimethyl acetamide; sulfuric acid; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,2-dichloro-ethane; toluene;

DOI:10.1021/jo001281w

Reference yield:

4-amino-1-benzylpiperidine (50541-93-0) → 1-(4-formylphenyl)-4-phthalimidopiperidine (321733-40-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 90 percent / N,N-dimethylacetamide / 8 h / Heating

2.1: 1,2-dichloro-ethane / 3 h / Heating

2.2: 82 percent / MeOH / 2 h / Heating

3.1: 30 percent / BINAP; t-BuOK / Pd₂(dba)3 / toluene / 6 h / 80 °C

4.1: 86 percent / aq.H₂SO₄; trifluoroacetic acid / 2 h / 20 °C

With N,N-dimethyl acetamide; sulfuric acid; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,2-dichloro-ethane; toluene;

DOI:10.1021/jo001281w

upstream raw materials:

1-[4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl]-4-phthalimidopiperidine

phthalic anhydride

4-amino-1-benzylpiperidine

2-(piperidin-4-yl)isoindoline-1,3-dione