(3R,4S)-1-(tert-Butoxycarbonyl)-4-(4-(trifluoroMethyl)phenyl)pyrrolidine-3-carboxylic acid

Base Information

Chemical Name:(3R,4S)-1-(tert-Butoxycarbonyl)-4-(4-(trifluoroMethyl)phenyl)pyrrolidine-3-carboxylic acid
CAS No.:1227844-93-0
Molecular Formula:C17H20F3NO4
Molecular Weight:359.345
Hs Code.:
Mol file:1227844-93-0.mol

Synonyms:(3R,4S)-1-(tert-Butoxycarbonyl)-4-(4-(trifluoroMethyl)phenyl)pyrrolidine-3-carboxylic acid

Suppliers and Price of (3R,4S)-1-(tert-Butoxycarbonyl)-4-(4-(trifluoroMethyl)phenyl)pyrrolidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of (3R,4S)-1-(tert-Butoxycarbonyl)-4-(4-(trifluoroMethyl)phenyl)pyrrolidine-3-carboxylic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3R,4S)-1-(tert-Butoxycarbonyl)-4-(4-(trifluoroMethyl)phenyl)pyrrolidine-3-carboxylic acid

There total 9 articles about (3R,4S)-1-(tert-Butoxycarbonyl)-4-(4-(trifluoroMethyl)phenyl)pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1227844-93-0,955137-85-6
(3R,4S)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With water; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: C₂₇H₂₉F₃N₂O₅

: 1227844-93-0,955137-85-6
(3R,4S)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/acs.jmedchem.8b01972

Reference yield:

: C₂₂H₂₈F₃NO₅

: 1227844-93-0,955137-85-6
(3R,4S)-1-(tert-butoxycarbonyl)-4-(4-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium chloride / tetrahydrofuran / 4 h / -20 - 20 °C

2: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

With water; lithium chloride; lithium hydroxide; In tetrahydrofuran;
DOI:10.1021/acs.jmedchem.8b01972