METHYL 4-TRIFLUOROMETHYLCINNAMATE

Base Information

• Chemical Name: METHYL 4-TRIFLUOROMETHYLCINNAMATE
• CAS No.: 20754-22-7
• Molecular Formula: C11H9 F3 O2
• Molecular Weight: 230.186
• Hs Code.: 2916399090
• Mol file: 20754-22-7.mol

Synonyms:2-Propenoicacid, 3-[4-(trifluoromethyl)phenyl]-, methyl ester, (E)-; Cinnamic acid, p-(trifluoromethyl)-,methyl ester, (E)- (8CI)

Chemical Property of METHYL 4-TRIFLUOROMETHYLCINNAMATE

Chemical Property:

• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 256.8°Cat760mmHg
• Flash Point: 91.4°C
• PSA: 26.30000
• Density: 1.251g/cm³
• LogP: 2.89160

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-Trifluoromethylcinnamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-TRIFLUOROMETHYLCINNAMATE

There total 36 articles about METHYL 4-TRIFLUOROMETHYLCINNAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid (2062-26-2,87212-84-8,16642-92-5) + diazomethyl-trimethyl-silane (18107-18-1) → methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate (20754-22-7)

Guidance literature:

In methanol; hexane; benzene; at 0 - 20 ℃; for 0.5h;

Reference yield: 98.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + dichloroacetic acid methyl ester (116-54-1) → methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate (20754-22-7)

Guidance literature:

With chromium dichloride; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2004.05.113

Reference yield: 97.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate (20754-22-7)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.9b01835

upstream raw materials:

3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid

p-trifluoromethylphenyl bromide

acrylic acid methyl ester

4-Trifluoromethylbenzaldehyde

Downstream raw materials:

methyl (Z)-3-(4-trifluoromethylphenyl)acrylate

3-(4-trifluoromethylphenyl)-2-propen-1-ol

1-bromo-3-[4-(trifluoromethyl)phenyl]propane

3‐(4‐(trifluoromethyl)phenyl)propan‐1‐ol

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