(Acetylamino)(3-oxopropyl)malonic acid diethyl ester

Base Information

• Chemical Name: (Acetylamino)(3-oxopropyl)malonic acid diethyl ester
• CAS No.: 53908-65-9
• Molecular Formula: C12H19NO6
• Molecular Weight: 273.286
• Hs Code.: 2924199090
• Mol file: 53908-65-9.mol

Synonyms:(Acetylamino)(3-oxopropyl)malonic acid diethyl ester;DIETHYL 2-ACETAMIDO-2-(2-FORMYLETHYL)MALONATE

Chemical Property of (Acetylamino)(3-oxopropyl)malonic acid diethyl ester

Chemical Property:

• Melting Point: 140-141 °C
• Boiling Point: 435.4±45.0 °C(Predicted)
• PKA: 12.00±0.46(Predicted)
• PSA: 98.77000
• Density: 1.153±0.06 g/cm3(Predicted)
• LogP: 0.35750
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

DIETHYL 2-ACETAMIDO-2-(2-FORMYLETHYL)MALONATE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Diethyl 2-Acetamido-2-(2-formylethyl) Malonate is a reagent that is used in the hydrogenation and biosynthesis of lupin alkaloids.

Technology Process of (Acetylamino)(3-oxopropyl)malonic acid diethyl ester

There total 4 articles about (Acetylamino)(3-oxopropyl)malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acrolein (107-02-8,25068-14-8) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → 4-acetamido-4,4-bis(ethyloxycarbonyl)butyraldehyde (53908-65-9)

Guidance literature:

With ethanol; sodium ethanolate; at 3 - 7 ℃;

DOI:10.1021/ja01188a037

Reference yield:

ethyl 2-acetamido-4-cyano-2-ethoxycarbonylbutanoate (5440-42-6) → 4-acetamido-4,4-bis(ethyloxycarbonyl)butyraldehyde (53908-65-9) + acetylamino-(2-carbamoyl-ethyl)-malonic acid diethyl ester

Guidance literature:

With hydrogenchloride; diethyl ether; tin(ll) chloride; Reagens 4:Chloroform; Erwaermen des gebildeten SnCl₄-Komplexes mit Wasser auf 50grad;

DOI:10.1021/ja01188a037

Reference yield:

3-chloro-1,1-diethoxy-propane (35573-93-4) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → 4-acetamido-4,4-bis(ethyloxycarbonyl)butyraldehyde (53908-65-9)

Guidance literature:

With sodium ethanolate; Erhitzen des Reaktionsprodukts mit wss.H₂SO₄ auf 100grad;

DOI:10.1021/ja01188a037

upstream raw materials:

ethyl 2-acetamido-4-cyano-2-ethoxycarbonylbutanoate

sodium ethanolate

acrolein

2-acetylaminomalonic acid diethyl ester

Downstream raw materials:

Δ¹-pyrroline-5-carboxylate

acetylamino-(3-phenylhydrazono-propyl)-malonic acid diethyl ester

acetylamino-[3-(4-sulfamoyl-phenylhydrazono)-propyl]-malonic acid diethyl ester

ethyl N-acetyl-O-p-toluenesulfonyl-2-amino-2-ethoxycarbonyl-5-hydroxypentanoate

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