2-Cyclohexyl-1,2,3,4-tetrahydro-quinoline

Base Information

• Chemical Name: 2-Cyclohexyl-1,2,3,4-tetrahydro-quinoline
• CAS No.: 123629-22-1
• Molecular Formula: C15H21N
• Molecular Weight: 215.338
• Mol file: 123629-22-1.mol

Synonyms:2-Cyclohexyl-1,2,3,4-tetrahydro-quinoline

Chemical Property of 2-Cyclohexyl-1,2,3,4-tetrahydro-quinoline

Chemical Property:

• PSA: 12.03000
• LogP: 4.13160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyclohexyl-1,2,3,4-tetrahydro-quinoline

There total 13 articles about 2-Cyclohexyl-1,2,3,4-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-cyclohexylquinoline (1613-43-0) → (RS)-2-cyclohexyl-1,2,3,4-tetrahydroquinoline (123629-22-1)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium iodide; at 40 ℃; for 11h;

DOI:10.1002/chem.201201517

Reference yield: 79.0%

2-cyclohexyl-1,2-dihydroquinoline (123612-53-3) → (RS)-2-cyclohexyl-1,2,3,4-tetrahydroquinoline (123629-22-1)

Guidance literature:

With sodium; In ethanol; Heating;

DOI:10.1021/jm00004a013

Reference yield: 61.0%

(RS)-3-(2-bromophenyl)-1-cyclohexylpropan-1-amine → (RS)-2-cyclohexyl-1,2,3,4-tetrahydroquinoline (123629-22-1)

Guidance literature:

With sodium t-butanolate; ruphos; In toluene; at 110 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.1c07401

upstream raw materials:

2-Phenylquinoline

2-cyclohexylquinoline

2-cyclohexyl-1,2-dihydroquinoline

acetic acid

Downstream raw materials:

(S)-2-cyclohexyl-1,2,3,4-tetrahydroquinoline

Refernces

• 1、 Askey, Hannah E.,Grayson, James D.,Tibbetts, Joshua D.,Turner-Dore, Jacob C.,Holmes, Jake M.,Kociok-Kohn, Gabriele,Wrigley, Gail L.,Cresswell, Alexander J.. "Photocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines". supporting information. p. 15936 - 15945. Retrieved 2021/10/12.
• 2、 Kiyoi, Takao,York, Mark,Francis, Stuart,Edwards, Darren,Walker, Glenn,Houghton, Andrea K.,Cottney, Jean E.,Baker, James,Adam, Julia M.. "Design, synthesis, and structure-activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists". scheme or table. p. 4918 - 4921. Retrieved 2010/11/04.