2-Cyclohexylquinoline

Base Information

• Chemical Name: 2-Cyclohexylquinoline
• CAS No.: 1613-43-0
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• DSSTox Substance ID: DTXSID50550424
• Nikkaji Number: J247.550B
• Wikidata: Q82429786
• Mol file: 1613-43-0.mol

Synonyms:2-cyclohexylquinoline;1613-43-0;quinoline-2-cyclohexane;SCHEMBL3524818;DTXSID50550424;SXTSREYTDKPWAO-UHFFFAOYSA-N

Chemical Property of 2-Cyclohexylquinoline

Chemical Property:

• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 211.136099547
• Heavy Atom Count: 16
• Complexity: 220

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C2=NC3=CC=CC=C3C=C2

Technology Process of 2-Cyclohexylquinoline

There total 46 articles about 2-Cyclohexylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

quinoline (91-22-5) + cyclohexene (110-83-8) → 2-cyclohexylquinoline (1613-43-0)

Guidance literature:

With tricyclohexylphosphonium chloride; [(1,5-cyclooctadiene)₂RhCl]₂; In tetrahydrofuran; at 165 ℃; for 9.5h;

DOI:10.1021/ja070388z

Reference yield: 90.0%

(E)-3-(2-aminophenyl)-1-cyclohexylprop-2-en-1-one → 2-cyclohexylquinoline (1613-43-0)

Guidance literature:

In tetrahydrofuran; for 22h; Irradiation;

DOI:10.1039/c7ob00558j

Reference yield: 89.0%

2-Aminobenzyl alcohol (5344-90-1) + Cyclohexyl methyl ketone (823-76-7) → 2-cyclohexylquinoline (1613-43-0)

Guidance literature:

With silver trifluoromethanesulfonate; lithium bromide; In toluene; at 70 ℃; for 8h; Green chemistry;

DOI:10.1016/j.tetlet.2015.04.070

upstream raw materials:

2-cyclohexylquinoline-4-carboxylic acid

quinoline

1-bromocyclohexane

cyclohexane

Downstream raw materials:

(RS)-2-cyclohexyl-1,2,3,4-tetrahydroquinoline

(R)-2-cyclohexyl-1,2,3,4-tetrahydroquinoline

(S)-2-cyclohexyl-1,2,3,4-tetrahydroquinoline