3-Chloro-2-ethoxy-5-nitropyridine

Base Information

• Chemical Name: 3-Chloro-2-ethoxy-5-nitropyridine
• CAS No.: 874492-07-6
• Molecular Formula: C₇H₇ClN₂O₃
• Molecular Weight: 202.597
• Hs Code.: 2933399090
• Mol file: 874492-07-6.mol

Synonyms:3-Chloro-2-ethoxy-5-nitropyridine

Chemical Property of 3-Chloro-2-ethoxy-5-nitropyridine

Chemical Property:

• PSA: 67.94000
• LogP: 2.56510
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

3-Chloro-2-ethoxy-5-nitropyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-2-ethoxy-5-nitropyridine

There total 1 articles about 3-Chloro-2-ethoxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,3-dichloro-5-nitropyridine (22353-40-8) + ethanol (64-17-5) → 3-chloro-2-ethoxy-5-nitropyridine (874492-07-6)

Guidance literature:

ethanol; With 15-crown-5; sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

2,3-dichloro-5-nitropyridine; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00529

Reference yield:

3-chloro-2-ethoxy-5-nitropyridine (874492-07-6) → N-(5-chloro-6-ethoxypyridin-3-yl)-2-(4-(ethylsulfonyl)phenyl)-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: iron; acetic acid / tetrahydrofuran; water / 20 - 60 °C

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 °C / Inert atmosphere

With iron; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/acs.jmedchem.8b00529

upstream raw materials:

2,3-dichloro-5-nitropyridine

ethanol

Refernces

• 1、 -. "NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS". Paragraph 0258. . Retrieved 2017/09/15.