1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylic acid

Base Information

Chemical Name:1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylic acid
CAS No.:147406-22-2
Molecular Formula:C₁₃H₁₆O₄
Molecular Weight:236.268
Hs Code.:
DSSTox Substance ID:DTXSID401233385
Mol file:147406-22-2.mol

Synonyms:1-(3,4-DIMETHOXYPHENYL)CYCLOBUTANECARBOXYLIC ACID;147406-22-2;1-(3,4-DIMETHOXYPHENYL)CYCLOBUTANE-1-CARBOXYLIC ACID;SCHEMBL9260618;DTXSID401233385;AC4344;MFCD08442741;AKOS000125568;AB45232;MCULE-9191826953;AS-76658;SY156311;CS-0308831;EN300-134614;1-(3,4-DIMETHOXYPHENYL)CYCLOBUTANECARBOXYLICACID;Z361883630

Suppliers and Price of 1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylicacid
50mg
$ 200.00

American Custom Chemicals Corporation
1-(3,4-DIMETHOXYPHENYL)CYCLOBUTANECARBOXYLIC ACID 98.00%
10G
$ 1865.33

AK Scientific
1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylicacid
1g
$ 937.00

Acrotein
1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylicacid 97%
0.5g
$ 183.33

ACHEMBLOCK
1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylicacid 95%
5G
$ 520.00

Total 6 raw suppliers

Chemical Property of 1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylic acid

Chemical Property:

PSA：55.76000
LogP:2.21010
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:236.10485899
Heavy Atom Count:17
Complexity:285

Purity/Quality:

97% ^*data from raw suppliers

1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2(CCC2)C(=O)O)OC

Technology Process of 1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylic acid

There total 3 articles about 1-(3,4-Dimethoxyphenyl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.4%

: 147406-22-2
1-(3,4-dimethoxyphenyl)cyclobutanecarboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; for 12h; Reflux;

Reference yield:

: 147406-21-1
1-(3,4-dimethoxyphenyl)cyclobutanecarbonitrile

: 147406-22-2
1-(3,4-dimethoxyphenyl)cyclobutanecarboxylic acid

Guidance literature:: With potassium hydroxide; In ethylene glycol;

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 147406-22-2
1-(3,4-dimethoxyphenyl)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

1.2: 20 - 60 °C

2.1: sodium hydroxide / water / 24 h / Reflux

With sodium hydride; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1021/acs.jmedchem.9b00751