1-(3,4-Dimethoxyphenyl)cyclobutane-1-carbonitrile

Base Information

Chemical Name:1-(3,4-Dimethoxyphenyl)cyclobutane-1-carbonitrile
CAS No.:147406-21-1
Molecular Formula:C13H15NO2
Molecular Weight:217.268
Hs Code.:
DSSTox Substance ID:DTXSID50602210
Nikkaji Number:J2.314.098E
Wikidata:Q82499178
Mol file:147406-21-1.mol

Synonyms:1-(3,4-Dimethoxyphenyl)cyclobutanecarbonitrile;147406-21-1;1-(3,4-Dimethoxyphenyl)cyclobutane-1-carbonitrile;Cyclobutanecarbonitrile, 1-(3,4-dimethoxyphenyl)-;MFCD10690051;SCHEMBL2827366;DTXSID50602210;AC4343;AKOS009265691;SY225711;A919566

Suppliers and Price of 1-(3,4-Dimethoxyphenyl)cyclobutane-1-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-(3,4-Dimethoxyphenyl)cyclobutane-1-carbonitrile

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:217.110278721
Heavy Atom Count:16
Complexity:290

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2(CCC2)C#N)OC

Technology Process of 1-(3,4-Dimethoxyphenyl)cyclobutane-1-carbonitrile

There total 3 articles about 1-(3,4-Dimethoxyphenyl)cyclobutane-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 109-64-8
1,3-dibromo-propane

: 147406-21-1
1-(3,4-dimethoxyphenyl)cyclobutanecarbonitrile

Guidance literature:: With potassium hydroxide; tetrabutylammomium bromide; In toluene; for 1.75h; Heating;
DOI:10.1016/j.tetlet.2006.03.176

Reference yield: 58.9%

: 147406-21-1
1-(3,4-dimethoxyphenyl)cyclobutanecarbonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -10 - 0 ℃; for 1h; Inert atmosphere;

In N,N-dimethyl-formamide; mineral oil; at -10 - 10 ℃;

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 147406-21-1
1-(3,4-dimethoxyphenyl)cyclobutanecarbonitrile

Guidance literature:: 3,4-dimethoxyphenylacetonitrile; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

cyclobutane halide; In tetrahydrofuran; at 20 - 60 ℃;
DOI:10.1021/acs.jmedchem.9b00751