(1S,2S)-2-(Diphenylphosphino)-1,2-diphenylethylamine, min. 97%

Base Information

• Chemical Name: (1S,2S)-2-(Diphenylphosphino)-1,2-diphenylethylamine, min. 97%
• CAS No.: 1091606-67-5
• Molecular Formula: C26H24NP
• Molecular Weight: 381.457
• Mol file: 1091606-67-5.mol

Synonyms:(1S,2S)-2-(Diphenylphosphino)-1,2-diphenylethylamine, min. 97%;(S,S)-(+)-2-Diphenylphosphino-1,2-diphenylethylaMine, 97+%;(1S,2S)-2-(Diphenylphosphino)-1,2-diphenylethylamine kanata purity

Chemical Property of (1S,2S)-2-(Diphenylphosphino)-1,2-diphenylethylamine, min. 97%

Chemical Property:

• Melting Point: 87-93°C
• Boiling Point: 517.2±50.0 °C(Predicted)
• PKA: 8.12±0.10(Predicted)
• PSA: 39.61000
• LogP: 6.26090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: air sensitive

Purity/Quality:

97% ^*data from raw suppliers

(1S,2S)-2-(Diphenylphosphino)-1,2-diphenylethylamine, min. 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2S)-2-(Diphenylphosphino)-1,2-diphenylethylamine, min. 97%

There total 5 articles about (1S,2S)-2-(Diphenylphosphino)-1,2-diphenylethylamine, min. 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl (1S,2S)-2-(diphenylphosphino)-1,2-diphenylethylcarbamate (1206227-48-6) → (1S,2S)-2-(diphenylphosphino)-1,2-diphenylethanamine (1091606-67-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo902302c

Reference yield:

(1R,2S)-2-Amino-1,2-diphenylethanol (23190-16-1) → (1S,2S)-2-(diphenylphosphino)-1,2-diphenylethanamine (1091606-67-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium carbonate / water; tetrahydrofuran / 4 h / 0 - 20 °C

2: triethylamine; thionyl chloride / dichloromethane / 1.5 h / -40 °C / Inert atmosphere; Glovebox; Schlenk technique

3: rhodium(III) chloride hydrate; sodium periodate / water; acetonitrile; dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

4: tetrahydrofuran / 19.5 h / -78 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

5: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

With sodium periodate; thionyl chloride; rhodium(III) chloride hydrate; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1021/om5008083

Reference yield:

tert-butyl (1S,2R)-2-hydroxy-1,2-diphenylethylcarbamate (813459-59-5) → (1S,2S)-2-(diphenylphosphino)-1,2-diphenylethanamine (1091606-67-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; thionyl chloride / dichloromethane / 1.5 h / -40 °C / Inert atmosphere; Glovebox; Schlenk technique

2: rhodium(III) chloride hydrate; sodium periodate / water; acetonitrile; dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

3: tetrahydrofuran / 19.5 h / -78 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

4: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

With sodium periodate; thionyl chloride; rhodium(III) chloride hydrate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1021/om5008083

upstream raw materials:

tert-butyl (1S,2S)-2-(diphenylphosphino)-1,2-diphenylethylcarbamate

(1R,2S)-2-Amino-1,2-diphenylethanol

tert-butyl (1S,2R)-2-hydroxy-1,2-diphenylethylcarbamate

(4S,5R)-4,5-diphenyl-1,2,3-oxathiazolidine-3-carboxylic acid 1,1-dimethylethyl ester 2,2-dioxide

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