(R)-(+)-N-METHYL-1-PHENYLETHYLAMINE-D13

Base Information

• Chemical Name: (R)-(+)-N-METHYL-1-PHENYLETHYLAMINE-D13
• CAS No.: 357407-86-4
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 148.106
• Mol file: 357407-86-4.mol

Synonyms:(R)-(+)-N-METHYL-1-PHENYLETHYLAMINE-D13;(R)-(+)-alpha,N-Dimethylbenzylamine-d13

Chemical Property of (R)-(+)-N-METHYL-1-PHENYLETHYLAMINE-D13

Chemical Property:

• Refractive Index: 67 ° (C=2, CHCl3)
• PSA: 12.03000
• LogP: 2.35790

Purity/Quality:

99%min ^*data from raw suppliers

(R)-(+)-ALPHA-N-DIMETHYLBENZYLAMINE-D13 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(+)-N-METHYL-1-PHENYLETHYLAMINE-D13

There total 18 articles about (R)-(+)-N-METHYL-1-PHENYLETHYLAMINE-D13 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11(2)H12F3NO (357407-84-2) → (1R)-N,α-dimethylbenzylamine-d13 (357407-86-4)

Guidance literature:

C₁₁⁽²⁾H₁₂F₃NO; With ammonia; In methanol; at 20 ℃; for 63h;

With sodium hydroxide; water-d2; sodium chloride; In diethyl ether; Further stages.;

DOI:10.1021/ol010108z

Reference yield:

C11(2)H12F3NO → (1S)-N,α-dimethylbenzylamine-d13 (357407-86-4)

Guidance literature:

C₁₁⁽²⁾H₁₂F₃NO; With ammonia; In methanol; at 20 ℃; for 63h;

With sodium hydroxide; water-d2; sodium chloride; In diethyl ether; Further stages.;

DOI:10.1021/ol010108z

Reference yield:

(+/-)-1-phenylethyl bromide-d9 (68239-29-2) → (1S)-N,α-dimethylbenzylamine-d13 (357407-86-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 35.2 g / liquide ammonia / 14 h / 20 °C

2.1: (S)-(+)-mandelic acid / various solvent(s) / 3 h / 45 °C

2.2: 15 g / NaOH / H₂O / 0.5 h / 20 °C

3.1: 19.3 percent / pyridine; CH₂Cl₂ / 2 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

4.2: tetrahydrofuran / 11 h / 20 °C

5.1: NH₃ / methanol / 63 h / 20 °C

5.2: 10.7 g / D₂O; NaOH; NaCl / diethyl ether

With (S)-Mandelic acid; ammonia; sodium hydride; In tetrahydrofuran; pyridine; methanol; dichloromethane;

DOI:10.1021/ol010108z

upstream raw materials:

(+/-)-1-phenylethyl bromide-d9

(1S)-N-trifluoroacetyl-α-methylbenzylamine-d9

acetophenone-d5

benzene-d6

Refernces